Lung disease is the major cause of death in individuals suffering from cystic fibrosis (CF), with abnormal lung-lining fluids occurring already in early infancy. However the precise aetiology of CF lung disease is still poorly understood. We investigated the structural components of the airway surface-lining layer in targeted Cftr/Cftr mutant mice and non-CF controls. Five lungs per animal grou...

BACKGROUND AND OBJECTIVES The recent development of flexible hollow waveguides for MID-IR lasers may be utilized transendoscopically to ablate selectively neoplastic, superficial tissues within body cavities. Study goals are to investigate theoretically and experimentally heat distribution and thermal response of cavity lining, during CO2 laser minimally invasive surgery (MIS), and to thermally...

Minimal change nephropathy is relatively uncontroversial. This can be defined as the condition associated with the nephrotic syndrome in which glomeruli have no abnormality on light microscopy. Segmental sclerosing glomerular disorders are often called focal segmental glomerulosclerosis, one of the most controversial terms in kidney disease. The tubular opening is the earliest site at which seg...

Neurofibromatosis type 1 (NF1) and type 2 both occur in mosaic (segmental) forms. When NF1 (and other autosomal dominant skin disorders) 2 occurs in a linear, patchy, quadrant, or otherwise localised form, two different types of mosaicism can be distinguished. Type 1 segmental involvement reflects heterozygosity for a postzygotic mutation occurring in an otherwise healthy embryo. The segmental ...