نتایج جستجو برای: secreted frizzled

تعداد نتایج: 41281  

Journal: :Cell stem cell 2013
Mi-Hyeon Jang Michael A Bonaguidi Yasuji Kitabatake Jiaqi Sun Juan Song Eunchai Kang Heechul Jun Chun Zhong Yijing Su Junjie U Guo Marie Xun Wang Kurt A Sailor Ju-Young Kim Yuan Gao Kimberly M Christian Guo-li Ming Hongjun Song

Adult neurogenesis, the process of generating mature neurons from adult neural stem cells, proceeds concurrently with ongoing neuronal circuit activity and is modulated by various physiological and pathological stimuli. The niche mechanism underlying the activity-dependent regulation of the sequential steps of adult neurogenesis remains largely unknown. Here, we report that neuronal activity de...

Journal: :Cell 1997
Luc Leyns Tewis Bouwmeester Sung-Hyun Kim Stefano Piccolo Eddy M De Robertis

Frzb-1 is a secreted protein containing a domain similar to the putative Wnt-binding region of the frizzled family of transmembrane receptors. Frzb-1 is widely expressed in adult mammalian tissues. In the Xenopus gastrula, it is expressed and regulated as a typical Spemann organizer component. Injection of frzb-1 mRNA blocks expression of XMyoD mRNA and leads to embryos with enlarged heads and ...

Journal: :Stem cells 2013
Laurent Balenci Carl Wonders Brenda L K Coles Laura Clarke Derek van der Kooy

Rare retinal stem cells (RSCs) within the ciliary epithelium at the retinal margin of the adult mouse and human eyes can divide in vitro in the absence of growth factors to generate clonal, self-renewing spheres which can generate all the retinal cell types. Since no regenerative properties are seen in situ in the adult mammalian eye, we sought to determine the factors that are involved in the ...

2015
Garima Sharma Ashish Ranjan Sharma Eun-Min Seo Ju-Suk Nam

The Wnt signaling pathway is mediated by a family of secreted glycoproteins through canonical and noncanonical mechanism. The signaling pathways are regulated by various modulators, which are classified into two classes on the basis of their interaction with either Wnt or its receptors. Secreted frizzled-related proteins (sFRPs) are the member of class that binds to Wnt protein and antagonizes ...

Journal: :Human molecular genetics 2006
Xinhua Shu Brian Tulloch Alan Lennon Dafni Vlachantoni Xinzhi Zhou Caroline Hayward Alan F Wright

Late-onset retinal macular degeneration (L-ORMD) is an autosomal dominant condition resembling age-related macular degeneration (AMD) in which a key pathological feature is a thick extracellular sub-retinal pigment epithelial (RPE) deposit. L-ORMD is caused by mutation in the C1QTNF5 (CTRP5) short-chain collagen gene, but the disease mechanism is unknown. Here, we first show that wild-type C1QT...

Journal: :Frontiers in bioscience 2017
Carl T Gustafson Tewodros Mamo Avudaiappan Maran Michael J Yaszemski

The importance of the Wnt signaling cascade in the fields of developmental biology, regenerative medicine, cancer genetics, and neurobiology has fueled a wide search for potent pharmacological agents capable of controlling Wnt signaling. Numerous fields of study have lent assistance to this endeavor, yielding both natural and synthetic compounds that are capable of inducing or inhibiting Wnt at...

Journal: :Crystals 2023

Protein adsorption is essential for determining material biocompatibility and promoting adherent cell growth. In this study, we focused on the a-plane structure of hydroxyapatite (HAp). This closely resembles crystal plane where apatite exposed in long bones. We conducted protein experiments using HAp ceramics with a preferred orientation to a-planes (aHAp), employing bovine serum albumin (BSA)...

Journal: :Journal of cell science 2003
Yoshiaki Kawano Robert Kypta

The extracellular antagonists of the Wnt signalling pathway can be divided into two broad classes. Both classes of molecule prevent ligand-receptor interactions, but by different mechanisms: members of the first class, which include the sFRP (secreted Frizzled-related protein) family, WIF (Wnt inhibitory factor)-1 and Cerberus, primarily bind to Wnt proteins; the second class comprises certain ...

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