OBJECTIVE To assess compliance with oral penicillin prophylaxis in children with sickle cell disease and identify possible reasons for poor compliance. DESIGN Closed questionnaires given to parents of children with sickle cell disease and general practitioners in Brent. Urine samples from 23 children were tested for penicillin. SETTING Paediatric haematology clinic, Central Middlesex Hospit...

BACKGROUND Acute rheumatic fever and its sequels, rheumatic heart diseases, remain major unsolved preventable health problems in Kosovo population, particularly among the disadvantages indigenous Albanian and Egyptians people. In Kosovo, despite of performing secondary prophylaxis with benzathine penicillin, acute rheumatic fever hospitalization rates have remained essentially unchanged for the...

TO THE EDITOR—We read with interest the article by Ganesan et al [1] that addresses a key question in syphilis management regarding the optimal dose of benzathine penicillin G (BPG) for the treatment of early syphilis in human immunodeficiency virus (HIV)-infected patients [2]. In this retrospective cohort study of 350 Department of Defense beneficiaries with 393 episodes of early syphilis betw...

A 37-year-old Caucasian male, HIV-infected (CDC A2) in 2012 and on antiretroviral therapy, presented for a follow-up visit. On physical examination, a barely discernible light-colored macular rash was observed on the trunk, not involving the palms and soles. However, clear maculo-papular lesions were present over the proximal volar aspect of both forearms. Furthermore, well-demarked purplish, o...

OBJECTIVES To determine the prevalence of nasopharyngeal pneumococcus colonization in children with sickle cell disease undergoing penicillin prophylaxis, to identify risk factors for colonization and to serotype and determine antibiotic resistance in pneumococci obtained from those children. METHODS Between April 9, 2002 and February 28, 2003, 188 nasopharyngeal swabs were obtained from 98 c...

Purpose: To investigate the effect of combination benzathine penicillin and ceftriaxone in treatment latent syphilis elderly. 
 Methods: A total 70 elderly patients with treated First People’s Hospital Yichang from March 2020 to 2021 were enrolled this study. Control group (CG) comprised thirty-two penicillin, while 38 received placed study (SG). Therapeutic efficacy adverse reactions both...

OBJECTIVE We studied the prevalence of nasopharyngeal (NP) carriage, antimicrobial susceptibilities, and serotypes of Streptococcus pneumoniae (SP) in children with sickle cell disease (SCD) in the Mid-South. In addition, we examined risk factors for NP carriage of penicillin-resistant SP (PRSP). STUDY DESIGN Between July 1994 and December 1995, we obtained NP cultures from 312 children with ...

The crystallization of three catalytically inactive mutants of penicillin V acylase (PVA) from Bacillus sphaericus in precursor and processed forms is reported. The mutant proteins crystallize in different primitive monoclinic space groups that are distinct from the crystal forms for the native enzyme. Directed mutants and clone constructs were designed to study the post-translational autoprote...