نتایج جستجو برای: secalins sec

تعداد نتایج: 17871  

Journal: :Acta Crystallographica Section E Structure Reports Online 2009

Journal: :University of Pennsylvania Law Review and American Law Register 1943

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2004
Laurie D DeLeve Xiangdong Wang Liping Hu Margaret K McCuskey Robert S McCuskey

The phenotypic features of liver sinusoidal endothelial cells (SEC), open fenestrae in sieve plates and lack of a basement membrane, are lost with capillarization. The current study examines localization of CD31 as a marker for the dedifferentiated, nonfenestrated SEC and examines regulation of SEC phenotype in vitro. CD31 localization in SEC was examined by confocal microscopy and immunogold-s...

Journal: :RNA 2014
Lucía Otero Laura Romanelli-Cedrez Anton A Turanov Vadim N Gladyshev Antonio Miranda-Vizuete Gustavo Salinas

Selenocysteine (Sec) is encoded by an UGA codon with the help of a SECIS element present in selenoprotein mRNAs. SECIS-binding protein (SBP2/SCBP-2) mediates Sec insertion, but the roles of its domains and the impact of its deficiency on Sec insertion are not fully understood. We used Caenorhabditis elegans to examine SBP2 function since it possesses a single selenoprotein, thioredoxin reductas...

Journal: :Molecular and cellular biology 2012
Zhuojuan Luo Chengqi Lin Erin Guest Alexander S Garrett Nima Mohaghegh Selene Swanson Stacy Marshall Laurence Florens Michael P Washburn Ali Shilatifard

The elongation stage of transcription is highly regulated in metazoans. We previously purified the AFF1- and AFF4-containing super elongation complex (SEC) as a major regulator of development and cancer pathogenesis. Here, we report the biochemical isolation of SEC-like 2 (SEC-L2) and SEC-like 3 (SEC-L3) containing AFF2 and AFF3 in association with P-TEFb, ENL/MLLT1, and AF9/MLLT3. The SEC fami...

Journal: :The Journal of biological chemistry 2005
Xue-Ming Xu Heiko Mix Bradley A Carlson Paula J Grabowski Vadim N Gladyshev Marla J Berry Dolph L Hatfield

Selenocysteine (Sec) is inserted into selenoproteins co-translationally with the help of various cis- and trans-acting factors. The specific mechanisms of Sec biosynthesis and insertion into protein in eukaryotic cells, however, are not known. Two proteins, SECp43 and the soluble liver antigen (SLA), were previously reported to interact with tRNA([Ser]Sec), but their functions remained elusive....

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