Acne in adolescents of developed countries is an epidemic skin disease and has currently been linked to the Western diet (WD). It is the intention of this viewpoint to discuss the possible impact of WD-mediated nutrient signalling in the pathogenesis of acne. High glycaemic load and dairy protein consumption both increase insulin/insulin-like growth factor-1 (IGF-1) signalling (IIS) that is sup...

Brunner's gland hyperplasia is a benign tumor of the duodenum and it is rarely associated with clinical symptoms. We report on a 64-yr-old man with Brunner's gland hyperplasia who had undergone a duodenocephalo-pancreatectomy. The reason is that he presented upper gastrointestinal obstructive symptoms and the esophagogastroduodenoscopic finding revealed the lesion to be an infiltrating type mas...

Transgenic mice were generated with different levels of human apolipoprotein C1 (APOC1) expression in liver and skin. At 2 mo of age, serum levels of cholesterol, triglycerides (TG), and FFA were strongly elevated in APOC1 transgenic mice compared with wild-type mice. These elevated levels of serum cholesterol and TG were due mainly to an accumulation of VLDL particles in the circulation. In ad...

Adiponectin plays important roles in metabolic function, inflammation and multiple biological activities in various tissues. However, evidence for adiponectin signaling in sebaceous glands is lacking, and its role remains to be clarified. This study investigated the role of adiponectin in lipid production in sebaceous glands in an experimental study of human sebocytes. We demonstrated that huma...

Case 1 A 39-year-old Japanese man presented with 6-month history of a group of papules on the chest (Figure 1A). The patient had no specific symptoms, such as itching or tenderness, but visited the clinic worried about the long duration of the lesions. Physical examination showed pinkish white, firm papules of 5 to 10 mm in diameter with sharply demarcated borders. The surface of the papules wa...

An otherwise healthy 38-year-old woman sought treatment for a right-sided progressively enlarging submandibular mass of 3 years’ duration. No significant personal or family history of malignancy was noted. The mass was initially measured as 2 × 1 cm. Three years later, on palpation, the mass was over the right submandibular area and was measured as 4 × 3 cm. It was soft and movable without tend...

localization of keratins and involucdn in solar keratosis and Bowen's disease. Am J Dermatopathol 1995; 17: 151-157. 4. Mai K.T. Alhalouly T. Landry D, Stinson WA. Perkins DG, Yazdi HM. Pagetoid variant of actinic keratosis with or with -out squamous cell carcinoma of sun-exposed skin: a lesion simulating extramammary Paget's disease. Histopathology 2002; 41:331-336. 5. Ansai S. Mihara I. Sebac...