Sir, The association of a speckled lentiginous naevus, an organoid naevus with sebaceous differentiation and skeletal and neurological anomalies, constitutes a specific syndrome that has been called phacomatosis pigmentokeratotica (1). It has been hypothesized that the co-occurrence of the two different naevi reflects a so-called twin spot phenomenon (1 – 3). We herein describe an additional ca...

The skin epidermis is a stratified epithelium that forms a barrier that protects animals from dehydration, mechanical stress, and infections. The epidermis encompasses different appendages, such as the hair follicle (HF), the sebaceous gland (SG), the sweat gland, and the touch dome, that are essential for thermoregulation, sensing the environment, and influencing social behavior. The epidermis...

© 2011 The Authors. doi: 10.2340/00015555-1133 Journal Compilation © 2011 Acta Dermato-Venereologica. ISSN 0001-5555 Epidermal naevus syndromes include different diseases that share a common feature of mosaicism (1, 2). The association of a speckled lentiginous naevus, an organoid naevus with sebaceous differentiation, with skeletal and neurological anomalies, constitutes a specific syndrome ca...

431 ImageS nosis from basal cell carcinoma originating from the sebaceous gland. In the erythematous mass containing the nevus sebaceous, a wide excision was performed with a safety margin of 5 mm. A frozen section biopsy showed that there were no tumor cells on the resection margin. Following the resection, scalp defects of 2.5×5.0 cm in size remained (Fig. 2). The defects were reconstructed u...

Sebaceous-gland carcinoma can occur alone or as one of the defining features of the Muir-Torre syndrome. Cases occurring below the head and neck are extremely rare. Here we describe the case of a 70-year-old male with Muir-Torre syndrome who had a recurrent sebaceous-gland carcinoma in the left lower extremity that demonstrated (18)F-FDG avidity. An (18)F-FDG-avid lower-extremity sebaceous-glan...

Sebaceous hyperplasia (SH) is a proliferative abnormality of sebaceous glands, most often seen in elderly individuals. It consists of single or multiple, asymptomatic, small yellow papules with a central depression. The face is most commonly affected, but there have been reports of SH on the chest or genitalia. A lobular array of well-differentiated mature sebaceous lobules is noted on histolog...

Trichoblastoma is a rare benign trichogenic tumour with epithelial and mesenchymal components recapitulating the germinal hair bulb and associated mesenchyme. A 50- year- old male patient presented with slowly enlarging circumscribed solid nodule measuring 4x3x4.5 cm over the tip of the nose. Microscopy of tumour revealed nodular tumour spanning the entire dermis with collection of mesenchymal ...

Prostaglandins (PG) are detected in virtually all organs and cells, whereas their enhanced release follows inflammatory mechanisms. PG synthesis, especially of PGE2, PGD2 and PGF2a, also takes place in epidermal keratinocytes as a result of arachidonic acid (AA) metabolism (Kondoh et al, 1985; Pentland and Needleman, 1986) and is differentially supported by specific enzymatic systems, the const...

Sebaceous carcinoma (SEB) is the most important malignant tumor of the eyelid. Early diagnosis and proper treatment significantly improve the outcome. SEB should be differentiated histopathologically from basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). In this study, the expression of androgen receptor (AR) in SEB, SCC, and BCC was evaluated. AR was positive in all 19 SEB cases. O...

The predisposition to epithelial neoplasms in nevus sebaceous is well established; most tumors occur in adults and are benign. Hidradenoma is a relatively rare benign tumor of sweat gland origin that can rarely arise within a nevus sebaceous. We present an interesting case of a hidradenoma and sebaceoma arising within a nevus sebaceous and present a literature review of the 2 conditions. Even t...