نتایج جستجو برای: sdspage
تعداد نتایج: 173 فیلتر نتایج به سال:
The purpose of this experiment was to examine the stress response of wild type Arabidopsis thaliana to treatment with different sodium chloride concentrations. Previous research has shown that sodium chloride induces a stress response from plants in both a physical sense and molecular sense. The hypothesis was that the plants would exhibit a number of different stress responses including shorte...
Psychrotrophic Pseudomonas ADT3 (NCBI GenBank Acc.no.JX914667) is capable of growth on lipid as the sole carbon source. In this paper, we report the purification and characterization of an extracellular lipase from psychrotroph, isolated from soil sample of NyAlesund, Svalbard, Arctic region. The Pseudomonas ADT3 isolate produces lipase enzyme in the extracellular minimal media with only 1% oli...
Injury to stratified epithelia causes a strong induction of keratins 6 (K6) and 16 (K16) in post-mitotic keratinocytes located at the wound edge. We show that induction of K6 and K16 occurs within 6 h after injury to human epidermis. Their subsequent accumulation in keratinocytes correlates with the profound reorganization of keratin filaments from a pan-cytoplasmic distribution to one in which...
p57 is an imprinted gene located at the chromosomal locus 11p15.5. It is a cyclin-dependent kinase inhibitor belonging to the CIP/KIP family, which includes additionally p21 and p27. It is the least studied CIP/KIP member and has a unique role in embryogenesis. p57 regulates the cell cycle, although novel functions have been attributed to this protein including cytoskeletal organization. Molecu...
The nonsteroidal anti-inflammatory drug (NSAID) sulindac prevents experimental colon cancer and can regress precancerous polyps in humans. Sulindac sulfide inhibits cyclooxygenase (COX)-mediated prostaglandin synthesis and retards the growth of cultured colon cell lines primarily by inducing apoptosis. Given the known role of mitogen-activated protein kinase (MAPK) in signal transduction and th...
p57 is an imprinted gene located at the chromosomal locus 11p15.5. It is a cyclin-dependent kinase inhibitor belonging to the CIP/KIP family, which includes additionally p21 and p27. It is the least studied CIP/KIP member and has a unique role in embryogenesis. p57 regulates the cell cycle, although novel functions have been attributed to this protein including cytoskeletal organization. Molecu...
Continuous labeling and pulse-chase techniques were employed to study the synthesis and secretion of multiple forms of immunoreactive ,f?-endorphin by cultured dispersed rat anterior lobe cells and intact neurointermediate pituitary lobe. Cell and medium extract immunoreactive pendorphin (specific immunoprecipitation and radioimmunoassay) exhibiting a K,, similar to authentic ,&endorphin upon g...
Phospholipase C 2 (PLC 2) has been implicated in collageninduced signal transduction in platelets and antigen-dependent signaling in B-lymphocytes. It has been suggested that tyrosine kinases activate PLC 2. We expressed the full-length cDNA for human PLC 2 in bacteria and purified the recombinant enzyme. The recombinant enzyme was Ca -dependent with optimal activity in the range of 1 to 10 M C...
The γ-secretase complex plays a role in Alzheimer’s disease (AD) and cancer progression. The development of clinical useful inhibitors, however, is complicated by the role of the γ-secretase complex in regulated intramembrane proteolysis of Notch and other essential proteins. Different γsecretase complexes containing different Presenilin or Aph1 protein subunits are present in various tissues. ...
S100B is a calcium-binding protein with both extracellular and intracellular regulatory activities in the mammalian brain. We have identified a novel interaction between S100B and the dopamine D2 receptor. Our results also suggest that the binding of S100B to the dopamine D2 receptor enhances receptor signaling. This conclusion is based on the following observations: 1) S100B and the third cyto...
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