UNLABELLED The purpose of this study was to determine whether a genetic vulnerability for schizophrenia and/or health-risk behaviors among schizophrenic pregnant women were associated with an increased incidence of obstetric complications (OCs). METHOD A high-risk birth cohort was formed by searching the Finnish Perinatal Register for all births from 1991-2000 with arterial cord pH values bel...

BACKGROUND Processing of contextual information is essential for the establishment of good interpersonal relations and communicational interactions. Nevertheless, it is known that schizophrenic patients present impairments in the processing of contextual information. The aim of this study is to explore the influence of the remediation of context processing in schizophrenic patients. METHODS T...

The method of average error was modified tor research in schizophrenia and was used in establishing both the absolute auditory threshold and the threshold of unpleasantness. The results showed chronic schizophrenic patients had a higher absolute threshold but a lower threshold for when a tone became unpleasantly loud. The results add evidence that chronic schizophrenic patients find external st...

Electrical stimulation of the temporal lobe was performed in chronic schizophrenic patients to treat the auditory hallucinations. During electrical stimulation, there appeared different kinds of hallucinations. The characteristics of the hallucinations produced by the temporal lobe stimulation greatly differ from those of the schizophrenic hallucinations. Visual and auditory hallucinations by t...

The authors review studies of abnormal signs on clinical neurological examination of schizophrenic patients. In spite of a number of methodologic limitations, the cumulative evidence strongly argues that there are more neurological signs in schizophrenic patients than in nonpsychiatric control subjects. Although less consistent, there is considerable evidence of more neurological signs in schiz...

Disturbed neural development has been postulated as a crucial factor in the pathophysiology of schizophrenic psychoses. The neurobiochemical basis for such changes of cytoarchitecture and changed neural plasticity could involve an alteration in the regulation of neurotrophic factors. In order to test this hypothesis, BDNF and NT-3 levels in post-mortem brain tissue from schizophrenic patients w...

Most of the relatively firm evidence on the causal significance of recent stressful life events in episodes of schizophrenia comes from a handful of retrospective case-control studies of schizophrenic patients and from comparisons of schizophrenic patients with patients suffering from affective disorders. Some important additional evidence is available from studies of the occurrence of psychoti...

Schizophrenia is characterized by a diverse symptomatology that often includes positive, cognitive and negative symptoms. Current anti-schizophrenic drugs act at multiple receptors, but little is known about how each of these receptors contributes to their mechanisms of action. Screening of novel anti-schizophrenic drug candidates targeting single receptors will be based on biomarker assays tha...

Pre-morbid schizoid and schizotypal traits and social adjustment were assessed blind to diagnosis by interviewing the mothers of 73 consecutively admitted patients with DSM-III schizophrenia or affective psychosis. Analysis of factors associated with pre-morbid deficits showed a highly significant interaction of diagnosis with sex, such that schizophrenic men showed much greater pre-morbid impa...

Background: The present study was conducted to determine the prevalence of metabolic syndrome (Mets) in schizophrenic patients in a 6-month period of treatment with antipsychotic medication. Methods: In this study, 60 volunteer schizophrenic patients were included.  At the onset and 6 month after treated with antipsychotic medication, fasting blood sugar (FBS), serum triglyceride (TG), high de...