PURPOSE This phase I study assessed the maximum tolerated dose (MTD), safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of SJG-136, a sequence-specific DNA cross-linking agent, in patients with advanced cancer. EXPERIMENTAL DESIGN In schedule A, seven patients received escalating doses of SJG-136 (6, 12, 24, and 48 μg/m(2)) daily for 5 of 21 days. Blood samples were colle...

PT. X is a services and manufacturing company. Y one of some industrial companies use the X, biggest chemical fertilizer producer in Southeast Asia. PT uses 66 belt-conveyors for distributing material. In order to arrange maintenance schedule, used preventive calculations using Failure Mode Effect Critically Analysis method (FMECA). Preventive schedule conveyor belt’s components (belt primary c...

The present study replicates and extends previous research on stimulus control by arranging teacher attention for preschooler's mands into a multiple schedule and conducting a component analysis of the effects of schedule-correlated stimuli and contingency-specifying stimuli (rules) on the development of discriminated manding.

objective: experiencing ‎pleasant events during daily life ‎has a significant positive role in ‎the personal mental health and ‎acts as a keystone for “behavioral ‎activation” (ba) interventions. ‎there are serious differences in ‎the pleasant event schedules in ‎different cultures and countries. ‎we aimed to develop a persian ‎checklist of pleasant events ‎‎(pcpe) to provide and validate a ‎cu...

in today’s dynamic market, organizations must be adaptive to market fluctuations. in addition, studies show that material-handling cost makes up between 20 and 50 percent of the total operating cost. therefore, this paper considers the problem of arranging and rearranging, when there are changes in product mix and demand, manufacturing facilities such that the sum of material handling and rearr...

purpose: the present study examines the relationship between job related dimensions and job satisfaction of teaching staff of b-schools in india using structure equation modeling (lisrel 8.5). methodology: the study is based on a single cross-sectional survey. in all three hundred ten responses were generated from teachers of management institutes located inindia. a self-administered questionna...

Background There is increasing research to suggest that certain Schedule 1 drugs, most notably psychedelics, can be effective in treating a range of mental health disorders. However, due several practical, financial, and bureaucratic barriers, there lack large-scale trials into their efficacy. This study aimed explore the any facilitators, undertaking through examining different positions other...