نتایج جستجو برای: scf

تعداد نتایج: 3666  

Journal: :Blood 1994
Y Sonoda H Sakabe Y Ohmisono S Tanimukai S Yokota S Nakagawa S C Clark T Abe

We studied the synergistic effects of stem cell factor (SCF) and other burst-promoting activities (BPAs) such as interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor (GM-CSF), or IL-9 on proliferation of human peripheral blood-derived highly purified progenitors. SCF, IL-3, GM-CSF, and IL-9 showed significant BPA when CD34+HLA-DR+ cells were used as the target population. IL-3...

Journal: :Molecular cancer therapeutics 2006
Julie Litz Geoffrey W Krystal

Vascular endothelial growth factor (VEGF) is one of the most important mediators of tumor angiogenesis. In addition to hypoxia, peptide growth factors are known to regulate VEGF expression but the effect of stem cell factor (SCF), the ligand for c-Kit, on VEGF expression has not been characterized. We therefore studied the effect of SCF-mediated c-Kit activation on VEGF expression by the H526 s...

Journal: :Photonics 2023

In this work, we have proposed and optimized a segmented cladding fiber (SCF) with large mode area (LMA) consisting of uniform core double cladding. The outer the SCF consisted periodic alternation high- low-refractive-index segments, while inner resonant layer rods surrounded by high-refractive-index rings. three geometrical parameters chosen as design variables were (a) doped rod refractive i...

Journal: :modares journal of medical sciences: pathobiology 2014
seyed ali hashemi mohamad sajad emami aleagha mohsen emami aleagha abdolamir allameh

objective: acetaminophen (apap) overdose causes acute liver injuries. studies show that stem cell factor (scf) and its receptor, c-kit, enhance liver recovery from apap-induced injuries in mice. in this study we explore the effect of scf on activity of glutathione s-transferase (gsts) enzymes which are considered to be important in apap metabolism. methods: we divided 45 balb/c mice into three...

Journal: :Carcinogenesis 2008
Zhi-Bo Han He Ren Hui Zhao Ying Chi Ke Chen Bin Zhou Yong-jun Liu Lei Zhang Bin Xu Bin Liu Renchi Yang Zhong-Chao Han

Stem cell factor (SCF) plays important roles in tumor growth and angiogenesis. However, its regulatory mechanism remains largely undefined. Here, we report that hypoxia upregulated the expression of SCF in MCF-7 breast cancer cells in both messenger RNA and protein levels. When hypoxia-inducible factor (HIF)-1 alpha expression was knocked down by RNA interference, the MCF-7 cell expression of S...

2016
Hamidreza Sanati Reza Kiani Farshad Shakerian Ata Firouzi Ali Zahedmehr Mohammadmehdi Peighambari Leila Shokrian Peiman Ashrafi

BACKGROUND In some patients with chest pain, selective coronary angiography reveals slow contrast agent passage through the epicardial coronary arteries in the absence of stenosis. This phenomenon has been designated the slow coronary flow (SCF) phenomenon. OBJECTIVES In this study, we aimed to describe the demographic and clinical findings and presence of common atherosclerosis risk factors ...

Journal: :Blood 1992
V C Broudy F O Smith N Lin K M Zsebo J Egrie I D Bernstein

Stem cell factor (SCF) acts in concert with lineage-specific growth factors to stimulate the growth of hematopoietic colonies. To determine if neoplastic human hematopoietic cells would also respond to SCF, we cultured marrow mononuclear cells from 20 patients with newly diagnosed acute myelogenous leukemia (AML) and two normal donors with SCF, interleukin 3 (IL-3), granulocyte-macrophage colon...

Journal: :The International journal of developmental biology 2015
Thanida Srihawong Takashi Kuwana Kannika Siripattarapravat Chanin Tirawattanawanich

Avian primordial germ cells (PGCs) are destined to migrate a long distance from their extra embryonic region via the vascular system to the gonadal ridges where they form the germ cells. Although PGC migration is crucial for a genetic continuation to the next generation, the factors and mechanisms that control their migration remain largely unknown. In the present study the chemotactic effect o...

2011
Bum Sung Kim Hyun-Joong Kim Seong Woo Han Sung Hea Kim Soon Yong Suh Sang Man Chung Kyu Hyung Ryu

BACKGROUND AND OBJECTIVES Slow coronary flow (SCF) is characterized by delayed contrast dye opacification without significant stenosis of epicardial coronary arteries. However, the pathophysiology and clinical implications of SCF are not fully understood. Some reports have suggested that SCF might be caused by atherosclerosis in the coronary artery microvasculature. Measuring carotid intima-med...

2008
Naoki Yoshinaga

This paper proposes a method of constructing an accurate probabilistic subcategorization (SCF) lexicon for a lexicalized grammar extracted from a treebank. We employ a latent variable model to smooth co-occurrence probabilities between verbs and SCF types in the extracted lexicalized grammar. We applied our method to a verb SCF lexicon of an HPSG grammar acquired from the Penn Treebank. Experim...

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