A new spectrophotometric method for the determination of minute amounts of cholesterol in tissues is described. This method is a modification of the Yoshimatsu reaction which is basedon the reduction of the yellow aqueoussolution of phospho-6tungstic-12-molybdic acid by a solution of cholesterol in concentrated sulfuric acid. The color of the resulting hydrosol of “molybdenum/tungsten blue” is ...

A concise (5 to 6 steps), stereodivergent, highly diastereoselective (dr up to >19:1 for both stereoisomers) and scalable synthesis (up to 14 g) of cis- and trans-2-substituted 3-piperidinols, a core motif in numerous bioactive compounds, is presented. This sequence allowed an efficient synthesis of the NK-1 inhibitor L-733,060 in 8 steps. Additionally, a cyclodehydration-realizing simple triet...

Background and objectives: Amla is native to India and is exported to Iran. Although amla has been mentioned in Iranian traditional medicine (ITM) manuscripts, no pharmaceuticals have been prepared from this medicinal plant in Iran; thus, in the present study amla oil has been designed and formulated according to ITM. Methods: Phyllantus emblica and <e...

Individual tocopherol profile of five Agaricus mushroom species, widely consumed in Portugal, was obtained by a normal-phase high-performance liquid chromatography (NP-HPLC). It was used a simple solid-liquid extraction procedure without saponification step and the chromatographic separation was achieved using a YMC-Pack Polyamine II column using an isocratic elution with hexane/ethyl acetate (...