Introduction: Natural killer (NK) cells, of which CD56 is a specific marker, play an important role in host defense against tumors. Cancer stem cells, of which aldehyde dehydrogenase isoform 1 (ALDH1) is an immunohistochemical marker, are a group of tumorigenic cells which are involved in migration and tumor recurrences. We aimed to evaluate the expression of ALDH1 and CD56 in common salivary g...

TUMOURS of the salivary glands are relatively uncommon. From 1958 through 1968 a total of 77 lesions of all the salivary glands were seen by one of us (M.B.) and 67 involved the parotid, 8 the submaxillary, one the sublingual and one an ectopic gland. In this paper we present our experience with the 'partoid' lesions, which comprise the largest group in the series, 67 out of a total of 77, as e...

OBJECTIVES Salivary gland tumours (SGTs) are a group of heterogeneous lesions with complex clinico-pathological characteristics and distinct biological behaviours. Previous studies have reported geographic variations in site distribution, incidence and histological types of SGTs. The aim of this study was to describe the demography of SGTs seen at a tertiary health centre and compare findings w...

OBJECTIVE This study proposes a revision of the literature on the current techniques employed in salivary gland biopsy. METHODS A systematic review of the literature between January 1990 and January 2010 was conducted using MEDLINE, Embase and the Cochrane Central Register of Controlled Trials. The search terms were: 'biopsy AND parotid AND Sjögren'; 'biopsy AND sublingual salivary gland AND ...

Epithelial myoepithelial carcinoma is a rare biphasic low grade neoplasm of salivary glands; it most commonly occurs in the parotid gland but can also arise in minor salivary glands. Here a case of 58-year-old female presented with left cheek swelling of one-year duration. CT scan revealed a localized submandibular salivary gland tumor mass not involving surrounding tissues. Histological examin...

Tyrosine crystals were seen in 24 of 113 salivary gland pleomorphic adenomas from Malawi and one of six carcinomas arising in a pleomorphic adenoma; they were present in tumours from all common anatomical sites. They were not found in 71 other salivary tumours of varying histological type. Similar crystals were found in one out of 56 pleomorphic adenomas from patients operated on at St Thomas's...

Hemangiomas are defined as soft tissue lesions in the maxillofacial or oral region. Hemangiomas of salivary glands constitute 30% of the non-epithelial tumors in major salivary glands.  Benign tumors in salivary glands are located 85% in parotid gland and 13% in submandibular gland. We present a case of submandibular hemangioma in an infant patient that had some complications and a challenging ...

Spindle cell lipoma (SCL) is a rare distinct variant of lipoma, which presents as a painless, circumscribed, slow-growing, superficial lesion on the lip and can mimic a minor salivary gland tumour. We present a slow growing lower lip lesion and its management. Case Report. A 38-year-old female gave an eight-year history of a slow-growing mass on her lower lip with intermittent change in size. S...

Despite a pivotal role in salivary gland development, homeostasis, and disease, the role of salivary gland mesenchyme is not well understood. In this study, we used the Col1a1-GFP mouse model to characterize the salivary gland mesenchyme in vitro and in vivo. The Col1a1-GFP transgene was exclusively expressed in the salivary gland mesenchyme. Ex vivo culture of mixed salivary gland cells in DME...

Centrally occurring salivary gland tumors are rare. Because of a considerable overlap between the clinical and histopathological features, this group of tumors often produces a diagnostic difficulty to the clinicians and oral pathologists. Acinic cell carcinoma (ACC) is an unusual, low-grade, malignant salivary gland tumor that represents approximately 2% of the salivary gland tumors with almos...