A method for determining salicylates in ultramicro volumes of blood, spinal fluid, and urine has been investigated. This method combines the simplicity of one reagent for color development and deproteinization with a high degree of accuracy and precision. Apparent salicylate values in blood and spinal fluid of normal individuals are of the order of 0.7 mg./100 ml. The application of this method...

AIMS The penetration of active ingredients from topically applied anti-inflammatory pharmaceutical products into tissues below the skin is the basis of their therapeutic efficacy. There is still controversy as to whether these agents are capable of direct penetration by diffusion through the tissues or whether redistribution in the systemic circulation is responsible for their tissue deposition...

BACKGROUND/AIMS Salicylate and chlorpromazine exert differential effects on the chemokine release from mast cells. Since these drugs are amphiphilic and preferentially partitioned into the lipid bilayers of the plasma membranes, they would induce some morphological changes in mast cells and thus affect the process of exocytosis. METHODS Employing the standard patch-clamp whole-cell recording ...

A striking example of antagonistic drug effects (2) is afforded by the observation that in man salicylate, itself uricosuric in high dose, inhibits the pronounced uricosuria produced by probenecid (3, 4), sulfinpyrazone1 (5-9), and zoxazolamine (9-11). This suppressive action of salicylate has been assumed to be due to its successful competition with these drugs, and with uric acid, for renal t...

Ingestion of 1.5 g of aspirin, but not of sodium salicylate, produced a significant prolongation of the bleeding time in six normal male subjects when compared with the effects of a placebo. Similar differences in the effect of the two drugs on platelets was also observed. Aspirin ingestion resulted in impaired platelet aggregation by connective tissue and was associated with a decreased releas...

Salicylate administered to man in sufficiently large dosage (5 to 6 or more Gm. per day) causes marked uricosuria, characterized by substantially increased urate/inulin clearance ratios attributable to inhibition of tubular reabsorption of the filtered urate. In smaller dosage (1 to 2 Gm. per day) salicylate exerts a contrary effect, retention of urate, associated with lower than normal urate/i...

We investigated N-adamantyl-N'-phenyl urea derivatives as simple sEH inhibitors. Salicylate ester derivatives have high inhibitory activities against human sEH, while the free benzoic acids are less active. The methyl salicylate derivative is a potent sEH inhibitor, which also has high metabolic and chemical stabilities; suggesting that such inhibitors are potential lead molecule for bioactive ...

Methyl salicylate (MS) is widely available as a component in many over-the-counter brands of ointments, lotions, liniments and medicated oils intended for topical application [1]. Among the most potent forms of methyl salicylate is oil of wintergreen (98% MS). Salicylate ointment has a very high concentration of MS. One teaspoon contains 7000 mg MS, equivalent to 90 baby aspirin tablets.We repo...

Audiogenic seizure risk can be induced in genetically seizure-resistant BALB/c mice by exposure to an intense noise. Results of this experiment showed that combined exposure to noise and sodium salicylate could produce a greater priming effect than exposure to the noise alone, and the greatest potentiation effect was obtained when animals were exposed to the noise 6 hr after the intake of salic...