Milner, A. D., and Ingram, D. (1971). Archives of Diseases in Childhood, 46, 502. Bronchodilator and cardiac effects of isoprenaline, orciprenaline, and salbutamol aerosols in asthma. The bronchodilator and cardiac effects of 0-5% isoprenaline, 2 5% orciprenaline, and 0-5% salbutamol, and a placebo solution inhaled as a nebulized mist from a Wright nebulizer were compared with the help of 12 as...

The purpose of the present study was to investigate: 1) whether tidal flow patterns can be used to discriminate between children with asthma and those without respiratory illness; and 2) whether reversibility to salbutamol in young children can be detected by tidal breathing analysis? Lung function was measured by tidal flow-volume loops (SensorMedics 2600) in 26 awake young children (13 males)...

Inhalational insulin was withdrawn from the market due to its potential to produce airway hyper-reactivity and bronchoconstriction. So the present study was designed to explore the acute effects of insulin on airway reactivity of guinea pigs and protective effects of salbutamol and beclomethasone against insulin induced airway hyper-responsiveness on isolated tracheal smooth muscle of guinea pi...

The lung dose and deposition patterns of drug delivered by dry powder inhaler are not known. The effects of inhaling 400 micrograms salbutamol delivered by dry powder inhaler (two 200 micrograms salbutamol Rotacaps), by pressurised metered dose inhaler, and by Acorn nebuliser were studied in nine subjects with chronic stable asthma. Technetium-99m labelled Teflon particles were mixed with micro...

To examine possible augmentation of the effects of isosorbide dinitrate by salbutamol, haemodynamic measurements were made in 10 patients with severe chronic congestive cardiac failure who received isosorbide dinitrate 2.5 to 25 mg sublingually and salbutamol 4 to 12 mg orally, alone and in combination. Isosorbide dinitrate reduced mean left ventricular filling pressure from 29 to 18 mmHg and i...

AIMS To compare serum concentrations and effects on respiratory mechanics and haemodynamics of salbutamol administered by small volume nebuliser (SVN) and metered dose inhaler (MDI) plus spacer. METHODS Blinded, randomised, crossover study in 12 intubated infants and children (mean age 17.8 months) receiving inhaled salbutamol therapy. Subjects received salbutamol as 0.15 mg/kg by SVN and fou...

Organophosphates induce bronchoobstruction in guinea pigs, and salbutamol only transiently reverses this effect, suggesting that it triggers additional obstructive mechanisms. To further explore this phenomenon, in vivo (barometric plethysmography) and in vitro (organ baths, including ACh and substance P concentration measurement by HPLC and immunoassay, respectively; intracellular Ca2+) measur...

The aim of the present study was to investigate the in vitro effects of the short-acting β2-adrenoceptor agonist salbutamol and the long-acting β2-adrenoceptor agonist salmeterol on hypoxia-induced rat diaphragm force reduction. In vitro diaphragm twitch force (Pt) and maximal tetanic force (Po) of isolated diaphragm muscle strips were measured for 90 min during hyperoxia (tissue bath [Formula:...

BACKGROUND Awake tracheal intubation may evoke reflex bronchoconstriction in asthmatics. Whether this effect is altered by the choice of the local anesthetic used or by pretreatment with a beta2-adrenoceptor agonist is unknown. Therefore, we assessed the effect of awake fiberoptic intubation after lidocaine or dyclonine inhalation with or without pretreatment with salbutamol on lung function in...

Van der Heijden, H. F. M., L. M. A. Heunks, H. Folgering, C. L. A. van Herwaarden, and P. N. R. Dekhuijzen. b2-Adrenoceptor agonists reduce the decline of rat diaphragm twitch force during severe hypoxia. Am. J. Physiol. 276 (Lung Cell. Mol. Physiol. 20): L474–L480, 1999.—The aim of the present study was to investigate the in vitro effects of the short-acting b2-adrenoceptor agonist salbutamol ...