نتایج جستجو برای: sah

تعداد نتایج: 3039  

2005
Andreas Deussen Mathias Borst Keith Kroll JQrgen Schrader

Rate of accumulation of myocardial S-adenosylhomocysteine (SAH) was used in an open-chest dog preparation as an index of free cytosolic adenosine levels. Following 30 minutes of coronary artery ligation and infusion of L-homocysteine thiolactone (10 /umol/kg/min i.v.) SAH levels increased from 1.3 (control) to 3.3 nmoles/g in the nonischemic and to values over 100 nmoles/g in the ischemic regio...

Journal: :AJNR. American journal of neuroradiology 2001
R J Woodcock J Short H M Do M E Jensen D F Kallmes

BACKGROUND AND PURPOSE Fluid-attenuated inversion recovery (FLAIR) MR imaging sequences have been previously described in the evaluation of acute subarachnoid hemorrhage (SAH) in human subjects and have demonstrated good sensitivity. The purpose of this study was to evaluate a FLAIR sequence in an animal model of SAH and to compare the results with those obtained with non-contrast-enhanced CT. ...

Journal: :Molecules 2013
Chun Wu George Tzertzinis

A competitive immunoassay for S-adenosyl-L-homocysteine (SAH) has been used in the clinical test for homocysteine via an enzymatic conversion reaction. Since S-adenosyl-l-homocysteine is a relatively unstable compound, we have used peptide library phage display to select a new mimotope peptide that interacts with the anti-SAH antibody. By immobilizing the synthetic peptide on solid phase as a c...

Journal: :The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 2005
Nancy McLaughlin Michel W Bojanowski François Girard André Denault

BACKGROUND Pulmonary edema (PE) can occur in the early or late period following subarachnoid hemorrhage (SAH). The incidence of each type of PE is unknown and the association with ventricular dysfunction, both systolic and diastolic, has not been described. METHODS Retrospective chart review of 178 consecutive patients with SAH surgically treated over a three-year period. Patients with pulmon...

Journal: :Advances in experimental medicine and biology 2010
Noriaki Yokose Kaoru Sakatani Yoshihiro Murata Takashi Awano Takahiro Igarashi Sin Nakamura Tatsuya Hoshino Tsuneo Kano Atsuo Yoshino Yoichi Katayama Etsuko Ohmae Toshihiko Suzuki Motoki Oda Yutaka Yamashita

We examined the usefulness of near infrared time-resolved spectroscopy (TRS) for detection of vasospasm in subarachnoid hemorrhage (SAH). We investigated seven aneurysmal SAH patients with poor clinical conditions (WFNS grade V) who underwent endovascular coil embolization. Employing TRS, we measured the oxygen saturation (SO(2)) and baseline hemoglobin concentrations in the cortices. Measureme...

2014
Sheng Chen Qian Li Haijian Wu Paul R. Krafft Zhen Wang John H. Zhang

Subarachnoid hemorrhage (SAH) is a devastating neurological disorder. Patients with aneurysmal SAH develop secondary complications that are important causes of morbidity and mortality. Aside from secondary neurological injuries, SAH has been associated with nonneurologic medical complications, such as neurocardiogenic injury, neurogenic pulmonary edema, hyperglycemia, and electrolyte imbalance,...

Journal: :Journal of thrombosis and haemostasis : JTH 2014
C Muroi M Fujioka K Mishima K Irie Y Fujimura T Nakano J Fandino E Keller K Iwasaki M Fujiwara

BACKGROUND Microthrombosis and reactive inflammation contribute to neuronal injury after subarachnoid hemorrhage (SAH). ADAMTS-13 cleaves von Willebrand factor multimers, and inhibits thrombus formation and, seemingly, inflammatory reactions. OBJECTIVE To investigate the effect of ADAMTS-13 in experimental SAH. METHODS A total of 100 male C57/BL6 mice were randomly assigned to four groups: ...

Journal: :Stroke 2001
A Saito H Kamii I Kato S Takasawa T Kondo P H Chan H Okamoto T Yoshimoto

BACKGROUND AND PURPOSE The expression of inducible NO synthase (iNOS) after experimental subarachnoid hemorrhage (SAH) has been postulated to play a critical role in the pathogenesis of SAH and subsequent cerebral vasospasm. The inhibitory effect of CuZn-superoxide dismutase (CuZn-SOD) on the induction of iNOS after SAH was examined by using transgenic mice overexpressing CuZn-SOD. METHODS SO...

2018
Ji-Yang An Hong-Gang Pang Ting-Qin Huang Jin-Ning Song Dan-Dong Li Yong-Lin Zhao Xu-Dong Ma

High mobility group box 1 (HMGB1) is a classic damage-associated molecular pattern that has an important role in the pathological inflammatory response. In vitro studies have demonstrated that the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway is involved in the regulation of HMGB1 expression, mediating the inflammatory response. Therefore, th...

Journal: :Stroke 2009
Hidenori Suzuki Takumi Sozen Yu Hasegawa Wanqiu Chen John H Zhang

BACKGROUND AND PURPOSE We examined the effects of a caspase-1 inhibitor, N-Ac-Tyr-Val-Ala-Asp-chloromethyl ketone (Ac-YVAD-CMK), on neurogenic pulmonary edema in the endovascular perforation model of subarachnoid hemorrhage (SAH) in mice. METHODS Ninety-seven mice were assigned to sham, SAH+vehicle, SAH+Ac-YVAD-CMK (6 or 10 mg/kg), and SAH+Z-Val-Ala-Asp-fluoromethylketone (Z-VAD-FMK, 6 mg/kg)...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید