Teratoma formation is the gold standard assay for testing the capacity of human pluripotent stem cells to differentiate into all embryonic germ layers. Although widely used, little effort has been made to transform this qualitative assay into a quantitative one. Using gene expression data from a wide variety of cells, we created a scorecard representing tissues from all germ layers and extraemb...

31 cases of sacrococcygeal teratoma from the Children's Hospital of Ziirich and 25 cases from the Children's Hospital of Tehran are evaluated and compared. In seven cases the tumors were organized. They contained parts of organs or rudimentary extremities. According to general experience the malignancy of tumors is higher in children who are operated on after their second to fourth month o...

Teratomas are bizarre tumours which contain multiple tissues of kinds foreign to the part of the body in which they arise. Within teratomas these tissues can be organised into recognisable organs, limbs and, in some instances, structures which resemble a complete fetus (1,2,3). These 'monstrous' features give these tumours their name (teras=monster, in Greek). A common example of this bizarre d...

The differential diagnosis of cystic adnexal masses includes various pathologies, some placed extragonadally. Herein, we present two different cases of omental ovarian dermoid tumours that were diagnosed using ultrasonography and removed with surgery. The greater part of the omental teratomas appear to have developed from self-amputation of cysts in the ovary, followed by their re-implantation ...

INTRODUCTION The objective of this report is to describe the first patient presenting clinical features of trisomy 13 in association with a sacrococcygeal teratoma. CASE PRESENTATION We present the case of a Congolese female infant born with bilateral cleft lip and palate, hypotelorism, microcephaly, and capillary hemangioma on her face. She presented with a large sacrococcygeal mass (15.0 cm...

BACKGROUND Ovarian mature cystic teratomas are common, benign, pelvic tumors that are easily detected by pelvic ultrasonography. However, patients with recurrent teratomas are rarely noted, and cases of bilateral teratomas are even less common. CASE PRESENTATION A young woman with a recurrent, right ovarian teratoma had previously undergone surgical removal 2 times. After the second surgery, ...

Ependymomas, the common glial tumors of the spinal cord, occur occasionally outside the central nervous system and are called extraspinal ependymomas (ESE). ESE, which are clinically confused with other sacrococcygeal tumors, are rarely seen and found primarily in the sacrococcygeal region during childhood. We report a case of a seven-year-old boy presenting with a midline mass (6 cm diameter) ...

Benign cystic teratomas are the most common ovarian neoplasms in women. Teratomas are usually benign, unilateral, and most often found in young and premenopausal women. Most are 5 cm to 10 cm in diameter when diagnosed, and on sectioning, they usually contain thick sebaceous material, tangled hair, and various dermal structures. One of the major complications seen in cystic teratoma is torsion,...