The absence of a functional ATP Binding Cassette (ABC) protein called the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) from apical membranes of epithelial cells is responsible for cystic fibrosis (CF). Over 90% of CF patients carry at least one mutant allele with deletion of phenylalanine at position 508 located in the N-terminal nucleotide binding domain (NBD1). Biochemical and c...

Salmonella typhimurium is the causative agent of typhoid fever, which causes nearly 21.7 million illnesses and 217,000 deaths around the world each year. Here, we describe the draft genome sequences of the Salmonella typhimurium strains S7, S15, and S23, isolated from copper-fed pigs in Denmark and containing additional putative determinants conferring resistances to copper and other metals and...

Cardiovascular Disease in Dialysis Patients Tables ............................................................................................................................... S1 Figures ............................................................................................................................. S2 Acronyms and Abbreviations ......................................................

Enhancement of photoluminescence (PL) signal from Gd-doped silica glass densified by rapid thermal treatment (RTT) in the ultraviolet (UV) is investigated. Significant decrease of the loss covering the UV band is observed. The strong emission detected at 314 nm is assigned to the P7/2 to S7/2 transition under excitation of DJ, IJ, and PJ energy levels of the Gd.

The N-glycans of membrane glycoproteins are mainly exposed to the extracellular space. Human tyrosinase is a transmembrane glycoprotein with six or seven bulky N-glycans exposed towards the lumen of subcellular organelles. The central active site region of human tyrosinase is modeled here within less than 2.5 Å accuracy starting from Streptomyces castaneoglobisporus tyrosinase. The model accoun...