BACKGROUND AND OBJECTIVE Susceptibility to encapsulated bacteria is well known in sickle cell disease (SCD). Hydroxyurea use is common in adults and children with SCD, but little is known about hydroxyurea's effects on immune function in SCD. Because hydroxyurea inhibits ribonucleotide reductase, causing cell cycle arrest at the G1-S interface, we postulated that hydroxyurea might delay transit...

We describe new methods for the detection of immunoglobulin G (IgG) and IgM rubella-specific antibodies in serum. The IgG assay was based on a solid-phase rubella antigen immobilization approach, and the IgM assay was based on the IgM capture assay principle. Both assays used biotinylated antibodies (anti-human IgG and antirubella monoclonal antibody, respectively). The tracer system was based ...

Rubella is an acute, contagious viral infection caused by a teratogenic enveloped single-stranded RNA virus, rubella virus, a member of the togaviridae family. Though causing generally mild infections in children and adults, it is a disease of public health importance in pregnant women causing major problems including abortions, miscarriages, and congenital rubella syndrome in more than 20% of ...

BACKGROUND Rubella infection in pregnant women can result in serious effects, such as miscarriages, stillbirths, and congenital rubella syndrome (CRS). However, very little is known about the rubella seroprevalence among pregnant women in China. METHODS This is a cross-sectional and hospital-based study. From June 2016 through March 2017, a total of 324 serum samples from healthy pregnant wom...

Both rubella virus and Echovirus 9 (ECHO 9) were epidemic in Scotland during the summer of 1973; both viruses can cause a mild febrile illness with rash. Sera from 286 rubella-negative pregnant women were tested for neutralizing antibodies to ECHO 9 virus; 40 women had antibody titres suggestive of recent infection. Prospective studies on the outcome of these pregnancies are in progress but pre...

We report a prospective study of 56 pregnant women inadvertently vaccinated with rubella vaccine during the 2006 campaign performed in Argentina. Of these patients, 48 (87%) were immune, whereas the remaining 9 (16%) were susceptible. In the latter group, 7 presented with a primary reaction to the vaccine confirmed through immunoglobulin (Ig) G antibody avidity testing or seroconversion of IgG ...

in this report, a seroepidemiological survey was performed to determine the prevalence of rubella immunity and antibody titer in 11-16 year old girls in urban and rural areas of tonkabon district in northern iran. the results and conclusion are presented.

Received 3 May 2001; electronically published 20 September 2001. Reprints or correspondence: Dr. Louis Z. Cooper (Lzcooper @compuserve.com). Clinical Infectious Diseases 2001; 33:1287 2001 by the Infectious Diseases Society of America. All rights reserved. 1058-4838/2001/3308-0002$03.00 By using serum specimens from the third National Health and Nutrition Examination Survey, Dykewicz et al. [1]...

BACKGROUND & OBJECTIVES Congenital rubella syndrome (CRS) accounts for a significant amount of mortality and morbidity in India. Rubella vaccination is not included in our national immunization programme. Occupational exposure of the health care personnel to rubella infection is well known. This study aims to assess the serological status of health care workers against rubella virus in Aravind ...

Amongst neurological complications of rubella virus infection, polyradiculoneuritis as well as encephalitis is very rare. Only one case of postrubella polyradiculoneuritis combined with encephalitis has been reported to our knowledge. A 17-years-old male presented with suspected meningoencephalitis in a recent epidemic of rubella in a southern district of Korea. He developed symmetrical hyporef...