Abstract Precise ionospheric information, as like precise satellite orbits, clocks, and code/phase biases, is a critical factor for achieving fast integer ambiguity resolution in point positioning (PPP-AR). This study develops an ionosphere-weighted (IW) undifferenced uncombined PPP real-time kinematic (PPP-RTK) network model using code phase observations. We introduce between-station single-di...

Abstract Real-Time Kinematic Precise Point Positioning (PPP–RTK) is inextricably linked to external ionospheric information. The PPP–RTK performances vary much with the accuracy of information, which derived from different network scales, given prior variances, and obtained under disturbed conditions. This study investigates relationships between performances, in terms precision convergence tim...

Focal adhesion kinase (FAK) is a major drug target in cancer and current inhibitors targeted to the ATP-binding pocket of the kinase domain have entered clinical trials. However, preliminary results have shown limited single-agent efficacy in patients. Despite these unfavorable data, the molecular mechanisms that drive intrinsic and acquired resistance to FAK-kinase inhibitors are largely unkno...

The integration of Global Positioning System (GPS) real-time kinematics (RTK) and an inertial navigation system (INS) has been widely used in many applications, such as mobile mapping and autonomous vehicle control. Such applications require high-accuracy position information. However, continuous and reliable high-accuracy positioning is still challenging for GPS/INS integration in urban enviro...

DDR2 mutations occur in approximately 4% of lung squamous cell cancer (SCC) where the tyrosine kinase inhibitor dasatinib has emerged as a new therapeutic option. We found that ERK and AKT phosphorylation was weakly inhibited by dasatinib in DDR2-mutant lung SCC cells, suggesting that dasatinib inhibits survival signals distinct from other oncogenic receptor tyrosine kinases (RTK) and/or compen...

Chemotherapeutic and cytotoxic drugs are widely used in the treatment of cancer. In spite of the improvements in the life quality of patients, their effectiveness is compromised by several disadvantages. This represents a demand for developing new effective strategies with focusing on tumor cells and minimum side effects. Targeted cancer therapies and personalized medicine have been defined as ...

Molecular-targeted therapy against tyrosine kinase receptors (RTKs) plays an important role in gastric cancer (GC) treatment. Understanding the correlation between RTK coexpression could better guide clinical drug use. In the present study, the coexpression status of c-MET, fibroblast growth factor receptor 2 (FGFR2), and human epidermal growth factor receptor 2 (HER2) in human GC and their cli...

Traditionally structural response due to severe conditions has been measured using accelerometers. However it is a relative acceleration measurement. The displacement from acceleration measurement cannot be obtained directly by simply applying the laws of motion through double integration. GPS-RTK offers direct displacement measurements for dynamic monitoring, but it has its own limitations. Th...

Receptor tyrosine kinase (RTK) signaling plays an instructive role in cell fate decisions, whereas Notch signaling is often involved in restricting cellular competence for differentiation. Genetic interactions between these two evolutionarily conserved pathways have been extensively documented. The underlying molecular mechanisms, however, are not well understood. Here, we show that Yan, an Ets...

Unmanned aerial vehicles (UAVs) equipped with a global real-time kinematic navigation satellite system (GNSS RTK) could be state-of-the-art solution to measuring gaps in sugarcane fields and enable site-specific management. Recent studies recommend the use of UAVs map these gaps. However, low-accuracy GNSS provides incomplete or inaccurate photogrammetric reconstructions, which easily generate ...