Extreme black-swan occurrences like earthquakes, glacial lake outbursts, flash floods, landslides, etc. are important concerns in Himalayan countries Nepal, which highly susceptible, geologically active, and exquisitely fragile. Nepal generates 97 percent of its electricity from hydropower, where 56.08 it is coming seasonal run-off-river (RoR) hydro plants. Landslides mudflows common the monsoo...

Signal detection is one of the most advanced and promising techniques in world pharmacovigilance. Remdesivir approved for emergency use by US Food Drug Administration (FDA) patients with coronavirus disease 2019 (COVID-19). Its benefit- risk ratio still being explored because data field are rather scant. On other hand hyperkalemia a potentially life-threatening electrolyte disorder. Severe can ...

PD-1 inhibitors have emerged as a front-line treatment for several types of cancer based on their ability to support the immune system in attacking and shrinking tumors. However, inhibitor therapies are known be associated with irAEs. The study evaluated irAEs reported different organ classes by NSCLC patients treated therapies. was carried out using FAERS database limited period January 2015 S...

In this work, 8 weather variables were modeled at the Yabu meteorological station, Cuba, a daily database from of extreme temperatures, humidity and their average value, precipitation, was used. The force wind cloudiness corresponding to period 1977 2021, linear mathematical model is obtained through methodology Regressive Objective Regression (ROR) for each variable that explains behavior, dep...

Objective: This study aimed to examine the factors affecting consistency assumption with simulated data for network meta-analyses. Network pattern, number of studies per comparison, individual sample sizes, and probabilities event were investigated that may affect assumption. Material Methods: Data produced R 4.1.0 combination different sizes (N: 100, 150, 200), success probability three treatm...

Combinatorial gene inactivation using an RNAi library is a powerful approach to discovering novel functional genes. However, generation of a comprehensive RNAi library remains technically challenging. In this report, we describe a simple and novel approach to designing gene-family-specific RNAi libraries by targeting conserved motifs using degenerate oligonucleotides. We created an siRNA librar...

To clarify the association between carboplatin and electrolyte abnormality, a pooled-analysis was performed with the adverse event reports of non-small cell lung cancer patients. A total of 19901 adverse events were retrieved from the FDA Adverse Event Reporting System (FAERS). Pooled reporting odds ratios (RORs) and 95% CIs suggested that carboplatin was significantly associated with hyponatre...

ROR/RZR is an orphan nuclear receptor that has no known ligand in the ‘classical sense’. In the present study we demonstrate that RORα is constitutively expressed during the differentiation of proliferating myoblasts to post-mitotic multinucleated myotubes, that have acquired a contractile phenotype. Exogenous expression of dominant negative RORα1∆E mRNA in myogenic cells significantly reduces ...

Clopidogrel is an antiplatelet agent widely used in combination with aspirin to limit the occurrence of cardiovascular (embolic/thrombotic) events. Consensus guidelines recommend proton pump inhibitors (PPIs) as a gastrointestinal (GI) prophylactic measure for all patients receiving dual antiplatelet therapy with clopidogrel and aspirin. The objective of this study was to analyze the effect of ...

Wnt signaling is mediated by three classes of receptors, Frizzled, Ryk, and Ror. In Caenorhabditis elegans, Wnt signaling regulates the anterior/posterior polarity of the P7.p vulval lineage, and mutations in lin-17/Frizzled cause loss or reversal of P7.p lineage polarity. We found that pak-1/Pak (p21-activated kinase), along with putative activators of Pak, nck-1/Nck, and ced-10/Rac, regulates...