Retinopathy of prematurity (ROP) is a vasoproliferative retinal disorder that continues to be the major cause of preventable childhood blindness worldwide. Its incidence is inversely proportional to gestational age and birth weight. Approximately 65 percent of neonates with <1,250 g birth weight and 80 percent of those with 1,000 g birth weight will develop some degree of ROP. ROP can cause mil...

OBJECTIVES This study evaluated the incidence and risk factors for severe retinopathy of prematurity (ROP) in babies <1000 g at Porto Alegre, Brazil. METHODS Prospective cohort study including premature children with birth weight ≤1000 g was conducted. Main outcome was the occurrence of severe ROP needing treatment. RESULTS A total of 157 infants were included. Severe ROP occurred in 20 inf...

The appearance of retinopathy of prematurity (ROP) has changed throughout the world and since the first description of “retrolental fibroplasia” in 1942. However, despite advances in neonatal care and the abilities to improve the survival of ever younger and smaller premature infants, ROP remains a leading cause of childhood blindness worldwide. We know that ROP is complex in that it is influen...

Background: The most common cause of preventable blindness in children is retinopathy of prematurity (ROP). The most important risk factors for this disease are preterm delivery and low birth weight (LBW). This research was performed to evaluate the prevalence ofand risk factors for ROP in preterm neonates. Methods: Our research was a cross-sectional descriptive and retrospective study conduct...

BACKGROUND This study aimed to identify the main risk factors for development of retinopathy of prematurity (ROP) in neonatal intensive care units in Alexandria, Egypt, from January 2010 to January 2012. METHODS A prospective cohort study was undertaken in infants weighing < 1250 g and maternal postmenstrual age < 32 weeks if there was concern about prolonged exposure to oxygen. The main clin...

PURPOSE The clinical phenotype of advanced stage retinopathy of prematurity (ROP, stages 4 and 5) cannot be replicated in an animal model. To dissect the molecular events that can lead up to advanced ROP, we examined subretinal fluid (SRF) and surgically dissected retrolental membranes from patients with advanced ROP to evaluate its influences on cell proliferation, angiogenic properties, and m...

Dear Editor, Retinopathy of prematurity (ROP) is an ischemic retinopathy of premature and low birth weight infants. According to the early treatment for retinopathy of prematurity (ETROP) study, 68% of infants with birth weight less than 1,251 grams developed ROP of any degree. 1 ROP is a potentially blinding disorder and approximately 300 children per million live births have at least one eye ...

OBJECTIVE Retinopathy of prematurity (ROP) is the leading cause of childhood blindness in most developed countries. This study aimed to verify ROP prevalence among all very low birth weight (VLBW) preterm infants admitted to a level-3 teaching hospital in Porto Alegre, Rio Grande do Sul, Brazil. METHODS Institutional cross-sectional study of 407 premature infants with birth weight < or = 1,50...

OBJECTIVES Laser therapy is effective in the treatment of severe forms of retinopathy of prematurity (ROP), and aggressive posterior ROP (APROP), but always damages the retina. We report our preliminary findings in seven premature infants with complicated ROP or APROP who were treated with intravitreal bevacizumab (IVB) as first line monotherapy or rescue therapy combined with laser treatment. ...