PURPOSE The PETACC 6 trial investigates whether the addition of oxaliplatin to preoperative capecitabine-based chemoradiation and postoperative capecitabine improves disease-free survival (DFS) in locally advanced rectal cancer. METHODS Between November 2008 September 2011, patients with adenocarcinoma within 12 cm from anal verge, T3/4 and/or node positive, were randomly assigned 5 weeks (45-5...

Depuis une vingtaine d’années, un champ de recherche prolifique a pris pour objet les interactions entre mondes militants et économiques. Cette introduction du numéro thématique « Mondes militants, économiques : contestations, frontières, coopérations » en présente principaux axes, mais souligne également ses points ave...

Le changement climatique et la promotion de santé publique sont aujourd’hui au cœur des préoccupations citoyens gouvernements. Dans ce papier, nous contribuons à littérature en évaluant le lien entre précarité énergétique sur longue période. A l’aide modèles probit dynamiques, examinons l’influence santé. Nous co...

1 I n t r o d u c t i o n Adding parallel constants to a p rog ramming language strict ly increase the expressive power of the language, in general. For instance, extending Scot t ' s P C F with parallel-or, one can define any finite continuous funct ion [7]. However, it is an open problem whether parallelism adds expressive power, if we restrict our attent ion to total functions. Total i ty is...

Part ia l ly pur i f ied human l eukocy te (~) in te r fe ron was adminis tered i.m. at a dose of 3 x 106 u n i t s / d a y to 1 9 pa t ien ts w i th metas ta t i c renal cell ca rc inoma. Five pa t ien ts ( 2 6 % ) s h o w e d part ia l responses ; two pa t ien ts ( 10 .5%) , ob jec t i ve minor responses ; three pa t ien ts (16%) , m ixed e f fec ts (ev idence of b io log ica l e f fect w i t...

Selectin-dependent cell adhesion mediates inflammatory extravasation and routine homing of lymphocytes. Most resting peripheral T lymphocytes lack expression of sialyl Lewis X, the carbohydrate ligand for selectins, and are induced to strongly express it upon activation. T helper 1 (Th1) cells are known to more preferentially express sialyl Lewis X as compared with T helper 2 (Th2) cells upon a...

Coordinated programs of gene expression during cell differentiation can be controlled by master transcription factors. The differentiation of helper T (Th) lymphocytes during the immune response has been shown to occur along alternative pathways designated as Th1 and Th2. Induction of the Th1 and Th2 pathways is associated with the conversely regulated expression of the master factors T-bet and...