نتایج جستجو برای: roflumilast
تعداد نتایج: 449 فیلتر نتایج به سال:
BACKGROUND Inhalation of endotoxin (LPS) induces a predominantly neutrophilic airway inflammation and has been used as model to test the anti-inflammatory activity of novel drugs. In the past, a dose exceeding 15-50 μg was generally needed to induce a sufficient inflammatory response. For human studies, regulatory authorities in some countries now request the use of GMP-grade LPS, which is of l...
Inhaled bronchodilators and corticosteroids, when indicated, form the backbone of COPD therapy. However, over last decade there has been an emergence adjunct therapies in oral or inhaled that are now part therapeutic approach to COPD. While these have shown be beneficial used appropriate instances, particular considerations need minded using therapies. This review article discussed mechanism ro...
This study examined the pharmacologic characterization of CHF6001 [(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(3-(cyclopropylmethoxy)-4-(methylsulfonamido)benzoyloxy)ethyl)pyridine 1-oxide], a novel phosphodiesterase (PDE)4 inhibitor designed for treating pulmonary inflammatory diseases via inhaled administration. CHF6001 was 7- and 923-fold more potent than rofl...
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