Asymmetric dimethylarginine (ADMA) induces vascular smooth muscle cells (VSMCs) migration. VSMC phenotype change is a prerequisite of migration. RhoA and Rho-kinase (ROCK) mediate migration of VSMCs. We hypothesize that ADMA induces VSMC migration via the activation of Rho/ROCK signal pathway and due to VSMCs phenotype change. ADMA activates Rho/ROCK signal pathway that interpreted by the eleva...

rndetermination of rock mass deformation modulus is very important in different projects, especially in civil and mining engineering works. in-situ measurements such as dilatometer, plate load and flat jack methods may be applied to determine the deformation modulus. however, these methods are very expensive and time- consuming. analytical methods are very useful approaches which can also be us...

Rock abrasiveness is ability of rock to wear down the working tool during the mutual interaction between the working indentor and the rock in the mechanical rock cutting process. The cutting indentor is worn down during the interaction, which changes its geometric dimensions causing the enlargement of a contact area between the tool and the rock surface. The changes in these dimensions conseque...

In this paper we present a stereo feature-based method using SIFT (Scale-invariant feature transform) descriptors. We use automatic feature extractors, matching algorithms between images and techniques of robust estimation to produce a DTM (Digital Terrain Model) using convergent shots of a rock glacier.The geomorphologic structure observed in this study is the Veleta rock glacier (Sierra Nevad...

Malignant astrocytomas are highly invasive neoplasms infiltrating diffusely into regions of normal brain. Whereas the molecular and cellular mechanisms governing astrocytoma invasion remain poorly understood, evidence in other cell systems has implicated a role for the Rho-GTPases in cell motility and invasion. Here, we examine how the inhibition or activation of Rho-kinase (ROCK) affects astro...

Progression of tumors to invasive and metastatic forms requires that tumor cells undergo dramatic morphologic changes, a process regulated by Rho GTPases. Elevated expression of RhoA and RhoC, as well as the Rho effector proteins ROCK I and ROCK II, are commonly observed in human cancers and are often associated with more invasive and metastatic phenotypes. To examine how ROCK contributes to th...

by Hoek et al. 2002 and which is related to blasting, caused damage and stress relief; it may also be considered in the estimate of rock mass modulus from intact rock modulus. The recommendations of “D” values for tunnel and slope applications were provided by Hoek et al. 2002 . Unfortunately, no guidelines were provided for deep foundation application. The discussers related the disturbance fa...

Rho kinase (ROCK) is a well-known downstream effector of Rho and plays an important role in various physiopathological processes. In this study, we aim to investigate the correlation between ROCK and microvascular damage in rat brain subjected to middle cerebral artery occlusion (MCAO) and reperfusion, and to elucidate the mechanisms underlying the microvascular damage. ROCK and matrix metallop...