background this study aimed to evaluate the effectiveness of intravenous immunoglobulin (ivig) and combination of ivig and methylprednisolone for childhood idiopathic (autoimmune) thrombocytopenia (itp) treatment; in addition investigate the related factors to develop chronic form of under 15 years itp. materials and methods this retrospective study conducted on 88 itp patients that treated wit...

Indianapolis and Warsaw, Ind.; and Chicago, Ill. Learning Objectives: After studying this article, the reader should be able to: 1. Define the role of platelets in hemostasis and wound healing. 2. Describe the technologies for platelet concentration and application. 3. Characterize the platelet concentration and growth factor components of platelet-rich plasma. 4. List the potential application...

periodontal regeneration in a one-wall intrabony defect is a challenging and complex phenomenon. the combination therapy of commercially available bone grafts with the innovative tissue engineering strategy, the platelet rich plasma, has emerged as a promising grafting modality for two and three walled intrabony osseous defects. the application of this combination approach was attempted in a mo...

background and aims: plasma rich in growth factors (prgfs) has been recently proposed as an aid to enhance regeneration of osseous and epithelial tissues in oral surgery. the purpose of this study was to determine the effect of local application of platelet rich plasma (prp) on implant stability measured by periotest. materials and methods: a total of 24 implants were placed in mandible of 12 l...

Background and Purpose Platelet aggregation plays an important role in the pathogenesis of thromboembolic cerebrovascular disease. Leukocytes can efficiently stimulate as well as inhibit platelet aggregability. We studied the influence of leukocytes on collagen-induced platelet aggregation in patients with acute ischemic stroke. Methods We investigated 23 patients within 2 days after stroke and...

Background and Purpose Platelet aggregation plays an important role in the pathogenesis of thromboembolic cerebrovascular disease. Leukocytes can efficiently stimulate as well as inhibit platelet aggregability. We studied the influence of leukocytes on collagen-induced platelet aggregation in patients with acute ischemic stroke. Methods We investigated 23 patients within 2 days after stroke and...

OBJECTIVE To develop a flow cytometric assay to quantify platelet-derived microparticles (PMPs) in equine whole blood and plasma. SAMPLE Citrate-anticoagulated whole blood from 30 healthy adult horses. PROCEDURES Platelet-poor plasma (PPP) was prepared from fresh whole blood by sequential low-speed centrifugation (twice at 2,500 × g). Samples of fresh whole blood and PPP were removed and st...

Purpose To investigate the effect of partial ablation of melanopsin-containing retinal ganglion cells (mcRGCs) on nonimage-forming (NIF) visual functions in rd mice lacking rods. Methods The rd mice were intravitreally injected with different doses (100 ng/μl, 200 ng/μl, and 400 ng/μl) of immunotoxin melanopsin-SAP. And then, the density of ipRGCs was examined. After establishing the animal m...

Incubation of rabbit platelet-rich plasma with bacterial endotoxin results in activation of platelet factor 3, a precursor of blood thromboplastin. This platelet-endotoxin interaction is dose- and temperature-dependent, and is similar to the effects of antigen-antibody union in the presence of platelets. Injection of endotoxin intravenously is associated with a transient increase in platelet fa...