نتایج جستجو برای: ribosomal proteins
تعداد نتایج: 582395 فیلتر نتایج به سال:
The rate of synthesis of ribosomal proteins was investigated as an index of the rate of production of ribosomes in mouse kidney during the first few days after contralateral nephrectomy. Compensatory renal hypertrophy was not associated with a major increase in the synthetic rate of ribosomal proteins and rRNA. Instead, the ratio of the rate of ribosomal-protein synthesis to that of total prote...
Today the number of proteins [l-5] in eukaryotic ribosomal subunits as well as their molecular weights [6] are fairly well determined. Many of these proteins are also isolated and purified [3]. Just like histones, ribosomal proteins are very basic. Both kinds occur naturally in combination with nucleic acids: so it is likely that electrical charges play an important part in the association of t...
A system for naming ribosomal proteins is described that the authors intend to use in the future. They urge others to adopt it. The objective is to eliminate the confusion caused by the assignment of identical names to ribosomal proteins from different species that are unrelated in structure and function. In the system proposed here, homologous ribosomal proteins are assigned the same name, reg...
We have described a new method for the quantitative separation of ribosomal proteins and ribosomal ribonucleic acid. A procedure for the preparation of individual ribosomal proteins by polyacrylamide gel electrophoresis is also described. By the use of gels with smaller pores, at least four of the electrophoretic components from the 30S ribosome can be split into additional protein fractions. B...
Using antibodies to various nucleolar and ribosomal proteins, we define, by immunolocalization in situ, the distribution of nucleolar proteins in the different morphological nucleolar subcompartments. In the present study we describe the nucleolar localization of a specific ribosomal protein (S1) by immunofluorescence and immunoelectron microscopy using a monoclonal antibody (RS1-105). In immun...
The ribosome serves as the site of protein synthesis in all cells. Biogenesis of the mammalian ribosome is a complex process involving the coordinated expression of four ribosomal RNA molecules and approximately 75 ribosomal proteins. In order to understand the mechanisms governing ribosome biosynthesis, it is necessary to elucidate the structure and organization of its components. A cDNA clone...
Ribosome synthesis involves the coordinated folding and processing of pre-rRNAs with assembly of ribosomal proteins. In eukaryotes, these events are facilitated by trans-acting factors that propel ribosome maturation from the nucleolus to the cytoplasm. However, there is a gap in understanding how ribosomal proteins configure pre-ribosomes in vivo to enable processing to occur. Here, we have ex...
Ribosomes are macromolecular machines that synthesize all cellular proteins. Ribosome biogenesis requires huge expenditure of cellular energy, and its dysregulation can result in a number of diseases including cancer. In vitro reconstitution experiments of bacterial ribosomal subunits have revealed principles underlying the assembly of ribosomes. These principles are also thought to guide the m...
During protein biosynthesis, nascent protein chains are directed along a long narrow tunnel that spans the large ribosomal subunit. It has recently become clear that this structural feature has evolved to effect regulatory control over aspects of protein synthesis and protein trafficking. Since this control is nascent chain-specific, ribosomal components that form the tunnel must be involved in...
Plastid ribosomal proteins are essential components of protein synthesis machinery and have diverse roles in plant growth and development. Mutations in plastid ribosomal proteins lead to a range of developmental phenotypes in plants. However, how they regulate these processes is not fully understood, and the functions of some individual plastid ribosomal proteins remain unknown. To identify gen...
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