Protein and riboflavin deficiencies (11, 17, 1, 7) seem to be major dietary factors involved in the production of liver cancers by feeding p-dimethylaminoazobenzene. The quantity and type of fat in the diet also appear to be important in this process (14, 18), and other dietary factors, such as biotin, play a role under certain conditions (8, 22). Con versely, a major effect of feeding p-dimeth...

Mitochondrial dysfunction and oxidative stress are central to the molecular pathology of many human diseases. Riboflavin responsive multiple acyl-CoA dehydrogenation deficiency (RR-MADD) is in most cases caused by variations in the gene coding for electron transfer flavoprotein-ubiquinone oxidoreductase (ETF-QO). Currently, patients with RR-MADD are treated with high doses of riboflavin resulti...

F OR A MODEST SUM, Sigma Chemical Company will supply a diagnostic kit that will enable one to determine the glutathione reductase activity of the erythrocytes in a patient with hemolytic anemia. This kit or one or another assay procedure for glutathione reductase is used by conscientious physicians in the work-up of patients with chronic hemolysis. Unfortunately, the money and effort are waste...

A few reports were found on the riboflavin (B2) in the eye tissues in various species (1-3). Flavin compound in the eye of Rana nigromaculata concentrates in the choroid, iris, ciliary body and is not present in other parts. The amount and distribution of flavin compound in the eye varies considerably in different species of frogs (4). The presence of B2 in the lens of haddock (Gadus aeglefinus...

chronic alcohol abuse in drivers. Forensic Sci Int;in press. 6. Berkowicz A, Wallerstedt S, Wall K, Denison H. Carbohydrate-deficient transferrin in vitreous humour: a marker of possible withdrawal-related death in alcoholics. Alcohol 2001;36:231–4. 7. Helander A, Eriksson G, Stibler H, Jeppsson J-O. Interference of transferrin isoform types with carbohydrate-deficient transferrin quantificatio...

I t was reported in 1939 (2) that hepatic injury, mainly in the form of acute focal or diffuse necrosis combined with fat infiltration, occurred irregularly in young rats fed a diet devoid of vitamin B (casein 18 per cent, cane sugar 68, melted butter fat 8, cod liver oil 2, salt mixture 4) and supplemented with thiamine, riboflavin, and pyridoxine. In a group of more than 300 rats, 48 exhibite...

Both fluorometric and microbiological measurements of urinary riboflavin excretion have served as a basis for evaluation of nutritional status, detection of deficiency states, measurement of physiological availability, and determination of daily requirements. Fluorometric assay methods have commonly followed three basic procedures; namely, (a) that of Najjar (l), based on the extraction of ribo...