To the Editor: Dr Garbutt and colleagues reported the results of a randomized, placebo-controlled trial of adults with rhinosinusitis comparing a 10-day course of amoxicillin (1500 mg/d) with placebo administered in 3 doses per day. They concluded that the 10-day course of amoxicillin did not reduce symptoms after day 3 of treatment compared with placebo. However, the study has methodological l...

BACKGROUND We have previously shown that approximately 25% of those with asthma in West Sweden have multiple asthma symptoms, which may describe a group of patients with more severe disease. Furthermore, asthma is associated with several co-morbid diseases, including rhinitis and chronic rhinosinusitis. The aim of this study was to determine whether multi-symptom asthma is related to signs of s...

OBJECTIVE To assess whether change in endoscopy score correlates with change in health-related quality of life (HRQOL) following endoscopic sinus surgery for chronic rhinosinusitis. DESIGN Prospective open cohort. SETTING Tertiary rhinology clinic. PATIENTS One hundred two adult patients with and without nasal polyposis who elected to undergo endoscopic sinus surgery and were followed up ...

Chronic respiratory diseases such as asthma, allergic rhinitis (AR), chronic obstructive pulmonary disease (COPD), and rhinosinusitis are becoming increasingly prevalent in the Asia-Pacific region. The Asia-Pacific Burden of Respiratory Diseases (APBORD) study was a cross-sectional, observational study which examined the disease and economic burden of AR, asthma, COPD, and rhinosinusitis across...

Background Chronic rhinosinusitis (CRS) is one of common health conditions that affects patients' health-related quality of life. Our purpose is to assess the reliability and validity of Thai-version of Sino-Nasal Outcome Test 22 in chronic rhinosinusitis. Methods Permission for translation of SNOT-22 from English language to Thai language was obtained from the developer. The translation proc...

OBJECTIVES/HYPOTHESIS To describe the role and applicability of the EuroQol 5-Dimension, 5-Level (EQ-5D-5L) questionnaire for the assessment of general health-related quality of life in patients with chronic rhinosinusitis. STUDY DESIGN Prospective cohort study. METHODS The EQ-5D-5L was administered to 462 patients with refractory chronic rhinosinusitis before and 3 months after sinus surge...

OBJECTIVE Rhinologists are seeing an increasing number of immunosuppressed patients. Currently, no treatment paradigm exists for treating acute and chronic noninvasive rhinosinusitis (ARS, CRS) in this growing population. This study aims to identify patient and treatment factors that affect rhinosinusitis outcomes in this vulnerable population. STUDY DESIGN Prognostic retrospective cohort stu...

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