Abstract Introduction Peritoneal Metastasis (PM) in Colorectal Cancer (CRC) undoubtedly remains a challenge to treat and often portends poor prognosis for patients. Hyaluronic acid (HA) is found throughout the body, including coating of peritoneum. Interaction HA with HA-dependent adhesion molecules can facilitate cell within may play role spread PM CRC association known HA-receptor CD44, RHAMM...