For a generic n-degree polynomial system which contains n+1 polynomials in n variables, we give the construction of the generic mixed Cayley-Sylvester resultant matrix. There are n− 1 generic mixed Cayley-Sylvester resultant matrices between the classical Cayley resultant matrix and the classical Sylvester resultant matrix. The entries of these new resultant matrix are of degree m(1 < m < n + 1...