The product of the retinoblastoma (Rb) gene can form complexes with the transforming proteins of small DNA tumor viruses, including SV40 large T antigen (Tag), adenovirus E1A, and the human papilloma virus E7. The strong correlation between their ability to transform and their ability to bind Rb protein suggests that these oncoproteins exert their effect through blocking the Rb function. SV40 T...

We develop adaptive replicated designs for Gaussian process metamodels of stochastic experiments. Adaptive batching is a natural extension sequential design heuristics with the benefit replication growing as response features are learned, inputs concentrate, and metamodeling overhead rises. Motivated by problem learning level set mean simulator response, we five novel schemes: Multi-Level Batch...

Despite intensive breeding efforts, potato late blight, caused by the oomycete pathogen Phytophthora infestans, remains a threat to potato production worldwide because newly evolved pathogen strains have consistently overcome major resistance genes. The potato RB gene, derived from the wild species Solanum bulbocastanum, confers resistance to most P. infestans strains through recognition of mem...

many health studies were interested to find the association between multiple predictors with a dependent variable. the popular method to analyze these studies was multiple regressions that assumed the predictors were independent. while in practice some predictors may depend on each other and they could not be presented in a regression model simultaneously, as a result the appropriate models suc...

This demonstration shows the RB-HORST prototype running live on real hardware. RB-HORST offers WiFi offloading, video caching, and video prefetching based on social and overlay network predictions. RB-HORST is intended to run on home gateways/routers which are represented in the demo as low power computers. The demo will show the functionality of RB-HORST and how users can interact with the sys...

In this study, we investigate the three-body recombination (TBR) rates on both sides of interspecies $d$-wave Feshbach resonance in $^{85}\mathrm{Rb}$ -$^{87}\mathrm{Rb}\ensuremath{-}^{87}\mathrm{Rb}$ system using $R$-matrix propagation method hyperspherical coordinate frame. Our calculations are based Lennard-Jones model potential for Rb-Rb interaction. Two different mechanisms recombination-r...

Photodynamic therapy (PDT) is a promising treatment methodology whereby diseased cells and tissues are destroyed by reactive oxygen species (ROS) by using a combination of light and photosensitizers (PS). The medical application of Rose Bengal (RB), photosensitizer with very good ROS generation capability, is limited due to its intrinsic toxicity and insufficient lipophilicity. In this report, ...