Human metapneumovirus (hMPV) has been shown to be a leading cause of viral lower respiratory tract infections in children. Nevertheless, few reports regarding hMPV infections over consecutive years in children in primary care settings are available. We carried out virologic and clinical studies to determine the role of hMPV in febrile lower respiratory infections in children at a primary care c...

Respiratory syncytial virus (RSV) infection remains a major public health problem, especially in younger children and the elderly. But several monoclonal antibodies, antivirals vaccines, either recently launched or development, offer new hope for RSV prevention treatment.

Study objective: To define the epidemiology, clinical manifestations, and long-term complications of respiratory viral infections in adult lung transplant recipients. Design: Retrospective review of the records of 122 adult lung transplant recipients over a 5-year period at one institution. Results: Ten episodes of infection with respiratory syncytial virus, parainfluenza, influenza, or adenovi...

Upper respiratory tract infection (URTI) occurs commonly in both children and adults and is a major cause of mild morbidity. It has a high cost to society, being responsible for absenteeism from school and work and unnecessary medical care, and is occasionally associated with serious sequelae. URTIs are usually caused by several families of virus; these are the rhinovirus, coronavirus, parainfl...

ABSTRACT First Person is a series of interviews with the first authors selection papers published in Journal Cell Science, helping researchers promote themselves alongside their papers. Nannan Gao author on ‘ Respiratory syncytial virus disrupts airway epithelial barrier by decreasing cortactin and destabilizing F-actin’, JCS. postdoctoral fellow lab Fariba Rezaee, at Cleveland Clinic, Clevelan...

OBJECTIVE To determine whether early initiated anti-inflammatory therapy with prolonged high dose inhaled glucocorticoids influences the occurrence and severity of recurrent wheeze after respiratory syncytial virus related lower respiratory tract infections. DESIGN Randomised double blind placebo controlled trial. SETTING Paediatric departments of 19 Dutch clinical centres. PARTICIPANTS 2...

This study was performed to investigate the etiologic agents, age distribution, clinical manifestations and seasonal occurrence of acute viral lower respiratory tract infections in children. We confirmed viral etiologies using nasopharyngeal aspirates in 237 patients of the ages of 15 years or younger who were hospitalized for acute lower respiratory tract infection (ALRI) from March 1996 to Fe...

Respiratory tract infections (RTIs) are the most common diseases globally among children. This study aimed to assess epidemiology of admission-requiring pediatric RTI cases and evaluate effect pathogen type on length hospital stay (LOS) using FilmArray® respiratory panel, a multiplex PCR test. The age-specific distribution seasonality viruses were investigated between March 26, 2018 April 12, 2...

Human (HRSV) and bovine (BRSV) respiratory syncytial viruses (RSV) are two closely related viruses, which are the most important causative agents of respiratory tract infections of young children and calves, respectively. BRSV vaccines have been available for nearly 2 decades. They probably have reduced the prevalence of RSV infection but their efficacy needs improvement. In contrast, despite d...

Respiratory diseases are the most frequent chronic illnesses in babies and children. Although a vigorous innate immune system is critical for maintaining lung health, a balanced response is essential to minimize damaging inflammation. We investigated the functional and clinical impact of human genetic variants in the promoter of NFKBIA, which encodes IκBα, the major negative regulator of NF-κB....