The mitochondrial inner membrane contains two non-bilayer-forming phospholipids, phosphatidylethanolamine (PE) and cardiolipin (CL). Lack of CL leads to destabilization of respiratory chain supercomplexes, a reduced activity of cytochrome c oxidase, and a reduced inner membrane potential Δψ. Although PE is more abundant than CL in the mitochondrial inner membrane, its role in biogenesis and ass...

electrochemical energy stored as a proton gradient across the mitochondrial inner membrane (IM). To generate the proton gradient, the respiratory-chain complexes in the IM pump up protons from the matrix to the inter-membrane space by coupling it to the electron transport through the respiratory chain. The efficient electron flow relies on the respiratory-chain super-complex formation, which is...

OBJECTIVE Cerebral atrophy is a correlate of clinical progression in multiple sclerosis (MS). Mitochondria are now established to play a part in the pathogenesis of MS. Uniquely, mitochondria harbor their own mitochondrial DNA (mtDNA), essential for maintaining a healthy central nervous system. We explored mitochondrial respiratory chain activity and mtDNA deletions in single neurons from secon...

There is currently a great deal of interest in the streptomyces as producers of antibiotics, but relatively little is known about the mechanisms of intracellular energy supply in this group of organisms. They are aerobes, and carbohydrates serve as an energy source. There is good evidence that the pathways of carbohydrate metabolism in the streptomyces include the glycolysis sequence (Cochrane,...

OBJECTIVE Increased mechanical stress and contractility characterizes normal left ventricular (LV) subendocardium (Endo) but whether Endo mitochondrial respiratory chain complex activities is reduced as compared to subepicardium (Epi) and whether pressure overload-induced LV hypertrophy (LVH) might modulate transmural gradients through increased reactive oxygen species (ROS) production is unkno...

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