OBJECTIVES Praziquantel is the only drug available for the treatment of schistosomiasis and the state of the exhausted drug discovery pipeline is alarming. We restarted investigations on the abandoned antischistosomal Ro 13-3978, an aryl hydantoin discovered in the early 1980s by Hoffmann La-Roche. METHODS Newly transformed schistosomula and adult Schistosoma mansoni were studied in the prese...

In this paper the transfer function of a system with windowed current integration is discussed. This kind of integration is usually used in a sampling mixer and the current is generated by a transconductance amplifier (TA). The parasitic capacitance (Cp) and the output resistance of the TA (Ro,TA) before the sampling mixer heavily affect the performance. Calculations based on a model including ...

Vol. 25 No. 4, 2013 515 Received October 9, 2012, Revised December 17, 2012, Accepted for publication January 8, 2013 *These corresponding author contributed equally. Corresponding author: Jong Rok Lee, Department of Dermatology, Gachon University School of Medicine, 191 Hambangmoe-ro, Yeonsu-gu, Incheon 405-760, Korea. Tel: 82-32-460-2763, Fax: 82-32-460-2001, E-mail: [email protected]...

When a fire accident accompanied by an explosion occurs, the surrounding firewalls are affected impact and thermal loads. Damaged due to accidental loads may not fully perform their essential function. Therefore, this paper proposes advanced methodology for evaluating resistance performance of damaged explosions. The fragments were assumed be scattered, occurred as vehicle exploded in large com...

Intracellular Ca(2+) ([Ca(2+)] i ) is platelet aggregation-inducing molecule and is involved in activation of aggregation associated molecules. This study was carried out to understand the Ca(2+)-antagonistic effect of ginsenoside Ro (G-Ro), an oleanane-type saponin in Panax ginseng. G-Ro, without affecting leakage of lactate dehydrogenase, dose-dependently inhibited thrombin-induced platelet a...

Let G ⊂ S O (4 ) d e n o te a fi n ite su b g ro u p c o n ta in in g th e H e ise n b e rg g ro u p . In th e se n o te s w e c la ssify a ll th e se g ro u p s, w e fi n d th e d im e n sio n o f th e sp a c e s o f Gin v a ria n t p o ly n o m ia ls a n d w e g iv e e q u a tio n s fo r th e g e n e ra to rs w h e n e v e r th e sp a c e h a s d im e n sio n tw o . Th e n w e c o m p le te t...

A b str a c t C o n tro l in te n siv e IC s p o se a sign ifican t ch allenge to th e users o f fo rm a l m e th o d s in d esig n in g h ardw are. T h ese IC s h a ve to s u p p o r t a w id e v a r ie ty o f req u irem e n ts in clu d in g synchronous and asynchronous o p era ­ tion s, p o llin g an d in te rru p t-d riv e n m o d e s o f o p era tio n , m u ltip le con cu rrent th rea d s o...

s from The 34 Annual National Neurotrauma Symposium June 26–29, 2016 Lexington, Kentucky JOURNAL OF NEUROTRAUMA 33:A-1–A-139 (July 1, 2016) a Mary Ann Liebert, Inc. DOI: 10.1089/neu.2016.29008.abstracts D ow nl oa de d by N IH N A T IO N A L I N ST IT U T E S O F H E A L T H L IB R A R Y P A C K A G E f ro m o nl in e. lie be rt pu b. co m a t 0 2/ 14 /1 8. F or p er so na l u se o nl y.