Introduction: Drugs are mainly delivered to the target tissues by plasma proteins, such as human serum albumin, in the human body. Practical information about the thermodynamic parameters of drugs and their stability can be obtained using simulation methods, such as molecular docking. Material & Methods: This study, investigated the molecular docking of human serum albumin with fluorouracil an...

Background: Crinum purpurascens is a herbaceous plant belonging to the Amaryllidaceae family. We aimed to evaluate the antisalmonellal properties of the leaf extracts and fractions of C. purpurascens, and the toxicity of the most active extract. Methods: Three extracts and three fractions were prepared from the leaves of Crinum purpurascens Herb. (Amaryllidaceae) and tested for their antisalmon...

the aim of the present study was to evaluate the effects of sun-drying, ensiling and addition of polyethylene glycol (peg) on deactivation of tannins in the pistachio by-products hull (pbh). the chemical composition, protein quality and phenolic compounds of fresh pistachio by-products hull, sun-dried and ensiled for either 30 or 60 days were assessed. organic matter digestibility (omd) and met...

The proportion of the leaf blade, leaf sheath and stem fractions in six rice straw varieties averaged 30, 40 and 30%, respectively. In vitro dry matter digestibility (IVD) of these fractions, estimated by the cellulase-neutral detergent solution procedure, was 503, 513 and 610 g/kg, respectively. The lower IVD of the blade and sheath was due to lower degradation parameters estimated by a simple...

The enzymatic mechanisms involved in the degradation of phenanthrene by the white rot fungus Pleurotus ostreatus were examined. Phase I metabolism (cytochrome P-450 monooxygenase and epoxide hydrolase) and phase II conjugation (glutathione S-transferase, aryl sulfotransferase, UDP-glucuronosyltransferase, and UDP-glucosyltransferase) enzyme activities were determined for mycelial extracts of P....

Background Many elements such as immunosuppressive, chemotactic and anti-inflammatory peptide that could effect on human and animals physiologic system were determined in venom. This study evaluated the use of Mesobuthus eupeus scorpion venom fractions as an immunomodulator. Methods The venom fractions collected from Khuzestan Province in South West of Iran were purified by ion exchange chrom...

BACKGROUND TQ has been used as treatment and preventive agent for many diseases over the years. The goal of this study was to investigate the effects of TQ supplement on fractions of serum proteins. MATERIALS AND METHODS Fourteen male Wistar-Albino rats (200-250 g weight) were used as material for two groups; (control (C) and thymoquinone (TQ) respectively. Each group contained seven rats. Th...

A precise quantification of insect chitin is needed in order to avoid overestimation crude protein due chitin-bound nitrogen. An UPLC/FLR method was optimized and validated for the determination glucosamine (GlcN) hydrolyzed from materials. The applied quantifying content mealworms (Tenebrio molitor) crickets (Acheta domesticus). baseline separation obtained using an Acquity HSS T3 C18 column, ...