background : the demonstration that adipose tissue produces numerous   cytokines increases interest of investigators in their role in the pathogenesis of obesity. resistin is one of those cytokines. there are conflicing reports as cigarette smoking impairs insulin secretion, augments insulin resistance, or has no effect on glucose metabolism. in our study, we intended to examine the relationshi...

OBJECTIVE Adiponectin and resistin, two recently discovered adipocyte-secreted hormones, may link obesity with insulin resistance and/or metabolic and cardiovascular risk factors. We performed a cross-sectional study to investigate the association of adiponectin and resistin with inflammatory markers, hyperlipidemia, and vascular reactivity and an interventional study to investigate whether ato...

Diabetes remains one of the oldest diseases all over the world and is the major cause of morbidity and mortality in human populations. The pathology is a consequence of a lack of insulin or resistance to insulin, resulting in an increase in blood glucose levels. Resistance to insulin is an important risk factor in the industrial world and is often associated with obesity. Taking the proportions...

The development of human calcified aortic stenosis (AS) includes age-dependent processes that have been involved in atherosclerosis, such as infiltration of macrophages in aortic valves, which then promote production of many pro-inflammatory cytokines, including resistin. However, the molecular mechanisms contributing to these processes are not established. Since Sirt1 has been shown to modulat...

BACKGROUND Studies have revealed that resistin plays a role as an intrahepatic cytokine with proinflammatory activities. This study investigated the association between serum resistin and fibrosis severity and the possible marker role of resistin in the inflammatory process of chronic hepatitis B. METHODS In this study, 234 subjects with HBV infection were retrospectively selected, including ...

ABSTRACT Introduction: Apelin and resistin as novel adipokines have insulin-sensitizing effects, which may be associated with decreased blood glucose concentration. In this study, we aimed to investigate the impact of combined exercise training on plasma concentrations of apelin, resistin and insulin resistance in patients with type 2 diabetics male (T2D). Methods: In a quasi-...

Adipokines may represent a mechanism linking insulin resistance to cardiovascular disease. We showed previously that homocysteine (Hcy), an independent risk factor for cardiovascular disease, can induce the expression and secretion of resistin, a novel adipokine, in vivo and in vitro. Since vascular smooth muscle cell (VSMC) migration is a key event in vascular disease, we hypothesized that adi...

BACKGROUND Resistin is a major adipose tissue cytokine implicated in insulin resistance, inflammation and vascular damage. This cytokine is raised in patients with end-stage kidney disease (ESKD) but the relationship between resistin and major clinical outcomes has not been investigated in this population. METHODS We studied the mutual relationship between resistin and the two major adipokine...

INTRODUCTION Kawasaki disease (KD), an acute febrile disease, characterized by systemic vasculitis, predominantly affects infants and children under 5 years of age. Coronary artery lesions (CALs) are its most critical complication, and the etiology remains unknown yet. In order to explore the value of resistin, S100A12 and soluble receptor for advanced glycation end products (sRAGE) in the path...