Oxaliplatin is widely regarded as being active in cisplatin-resistant cancer. We undertook a systematic review of the literature to identify, describe and critique the clinical and pre-clinical evidence for the use of oxaliplatin in patients with "cisplatin-resistant" cancer. We identified 25 pre-clinical cell models of platinum resistance and 24 clinical trials reporting oxaliplatin based salv...

Multidrug-resistant tuberculosis (MDR) is perceived as a growing hazard to human health worldwide. Judgments about the true scale of the problem, and strategies for containing it, need to come from a balanced appraisal of the epidemiological evidence. We conclude in this review that MDR is, and will probably remain, a locally severe problem; that epidemics can be prevented by fully exploiting t...

linezolid in multidrug-resistant and extensively drug-resistant tuberculosis patients. Clin Pharmacokinet 2010; 49: 559–565. 9 Koh WJ, Kang YR, Jeon K, et al. Daily 300 mg dose of linezolid for multidrug-resistant and extensively drug-resistant tuberculosis: updated analysis of 51 patients. J Antimicrob Chemother 2012; 67: 1503–1507. 10 Srivastava S, Peloquin CA, Sotgiu G, et al. Therapeutic dr...

infectious diseases are responsible for thousands of worldwide early death .many commercial antibiotics have been used to control human's infectious diseases all over the world. calotropis procera linn a wild growing plant of asclepiadaecae family is known to possess multifarious medicinal properties. total 80 non repetitive clinical e. coli strains recovered during 7 month, and were screened f...

background studies revealed that severity of atopic dermatitis correlates with colonization by s.aureus and the density of bacteria and antibiotic resistance is one of the factors in s.aureus recolonization. objectives we aimed to determine the pattern of colonization with different subtypes of s.aureus in patients with atopic dermatitis and its correlation with scorad (scoring atopic dermatiti...

this study investigated the antibacterial resistance among enterococci isolated in tehran hospitals. a total of 277 enterococcus faecalis, 123 enterococcus faecium and 13 isolates of other enterococcal strains were collected from 1 march 2002 to 15 april 2004 from three teaching hospitals of tehran university of medical sciences. the minimum inhibitory concentrations (mic) of tested antibiotics...

the present study was conducted to investigate antimicrobial resistant pattern of escherichia coli (e. coli) strains isolated from clinical specimens of jordanian pediatric patients during the period from january to december 2008. a total of 444 e. coli strains were isolated from clinical specimens and tested for their susceptibility to different antimicrobial drugs. overall, high resistance ra...

background and objectives: carbapenem resistant a. baumannii is an emerging cause of nosocomial infections. the aims of this study were identification of the most prevalent of carbapenem resistant genes, molecular typing and antimicrobial evaluation of a.baumannii in intensive care units. materials and methods: two hundred and six a. baumannii were isolated from tracheal tube discharge of hospi...

background and objectives: infection with vancomycin-resistant enterococci (vre) has caused a therapeutic problem. vana and vanb resistant types are the predominant phenotypes among vancomycin resistant enetrococci. transposon 1546 (tn1546) harboring the vana gene cluster, plays an important role in the horizontal transfer of vana gene. in this study, we examined the phenotypic and genotypic di...