Vitiligo is an acquired pigmentry disorder of the skin and mucous membranes which manifests as white macules and patches due to selective loss of melanocytes. Etiological hypotheses of vitiligo include genetic, immunological, neurohormonal, cytotoxic, biochemical, oxidative stress and newer theories of melanocytorrhagy and decreased melanocytes survival. There are several types of vitiligo whic...

The most common and well known is nevus Sutton or halo nevus first described in medical journals in 1916, where a hypopigmented area develops around a pre-existing melanocytic nevus. Halo nevi undergo specific sequelae: In Stage I the nevus remains brown, in stage II its pigment can disappear leading to a pink-colored papule. In stage III the central papule disappears, leading to a circular are...

BACKGROUND To determine the susceptibility of teeth for repigmentation after bleaching. MATERIALS AND METHODS Forty premolars were assigned to three groups (n = 12). Group 1 was bleached using 30% w/v hydrogen peroxide 15 min 3 times a day every other day for 4 days. In Group 2 was bleached using 16% carbamide peroxide (Polanight), 90 min a day for 15 days. 2 days later, the shades of the ble...

Hair follicles and sweat glands are recognized as reservoirs of melanocyte stem cells (MSCs). Unlike differentiated melanocytes, undifferentiated MSCs do not produce melanin. They serve as a source of differentiated melanocytes for the hair follicle and contribute to the interfollicular epidermis upon wounding, exposure to ultraviolet irradiation or in remission from vitiligo, where repigmentat...

Vitiligo is an acquired pigmentary disorder caused due to a loss of functional melanocytes. Autologous non-cultured melanocyte transfer (NCMT) recent surgical modality for the treatment stable vitiligo. To evaluate clinical outcome NCMT in patients was performed on 41 They were evaluated at 1, 4, 12, 18 and 24 weeks post-surgery extent repigmentation complications. In this study, male- female r...

Gingival health and appearance are essential components of an attractive smile. Gingival pigmentation results from melanoblastic activity. ‘Black gums’ are common esthetic problem particularly in patients who have a very high smile line (gummy smile). Different treatment modalities have been reported for depigmentation of gingiva such as bur abrasion, scraping, partial thickness flap, cryothera...

Human subjects with active vulgar vitiligo do not respond well to autologous dermo-epidermal minigrafting. Eighteen subjects were treated with the alpha-melanocyte-stimulating hormone (alpha-MSH) synthetic analogue [Nle4, D-Phe7]-alpha-MSH. The hormone (50 microliters, 0.4 mM) was applied topically to 30-cm2 lesions in which 29-48 minigrafts had been made. The hormone did not improve the succes...

BACKGROUND Most treatment protocols for vitiligo require a long treatment duration and usually do not result in complete repigmentation. Therefore, cosmetically acceptable and easily to handle alternatives are warranted. OBJECTIVE To evaluate the properties of dihydroxyacetone (DHA) in a new formulation for the treatment of vitiligo on exposed areas. METHODS We treated 10 patients suffering...

Punctate leukoderma presents as numerous, distinct, round or oval depigmented spots. Recently, laser therapy-induced punctate leukoderma associated with various Q-switched laser and carbon dioxide laser have been reported. A 25-year-old man presented with numerous, discrete, round, confetti-like, depigmented macules on his left neck. He had undergone 3 sessions of 532-nm Q-switched Neodymium: Y...

Two men reported previously with vitiligo after occupational exposure to hydroquinone monomethyl ether (HMME) have been reviewed after eight years. Repigmentation of significant degree was found in one man and of limited degree in the other. One hundred and sixty-nine men in the same works have been screened with Wood's light for evidence of vitiligo. No cases were found in the 148 men exposed ...