BACKGROUND Renal cancer is a frequently occurring malignancy with over 270,000 new cases diagnosed and it being responsible for 110,000 deaths annually on a global basis. Incidence rates have gradually increased whilst mortality rates are starting to plateau. OBJECTIVE To review epidemiology and risk factors for renal cancer. METHODS The current data is based on a thorough review of availab...

BACKGROUND The finding of a renal mass on imaging is suggestive of metastatic non-small cell lung cancer in the presence of a lung tumor but can also have another origin. CASE REPORT We describe the case of a patient diagnosed with stage IV lung cancer based on a renal metastasis. A second opinion including review of histopathological data and additional imaging followed by lung surgery and c...

A 51-year-old male with a long history of tobacco smoking presented to the outpatient clinic with left renal colic. A renal ultrasound revealed a mass in the left kidney. The patient was admitted to surgical clinic of Russian Scientific Center of Roentgen-Radiology of Rosmedtechnology. A renal biopsy and subsequent histopathological tests revealed adenocarcinoma of the right kidney of most like...

Cancer 2012; 118: 6055–6062. 16. Kim J, Jonasch E, Alexander A et al. Cytoplasmic sequestration of p27 via AKT phosphorylation in renal cell carcinoma. Clin Cancer Res 2009; 15: 81–90. 17. Lin A, Piao HL, Zhuang L et al. FoxO transcription factors promote AKT Ser473 phosphorylation and renal tumor growth in response to pharmacologic inhibition of the PI3K-AKT pathway. Cancer Res 2014; 74: 1682–...

BACKGROUND Renal cell carcinoma (RCC) is the tenth most commonly diagnosed cancer in the United States. While it is usually lethal when metastatic, RCC is successfully treated with surgery when tumors are confined to the kidney and have low tumor volume. Because most early stage renal tumors do not result in symptoms, there is a strong need for biomarkers that can be used to detect the presence...

Exosome-based immunotherapy for cancer holds promise, but needs improvements, especially for tumor-derived exosomes. We investigated, whether exosomes derived from IL-12-anchored human renal cancer cells could enhance their immunogenicity and increase induction of specific antitumor response. A mammalian co-expression plasmid of glycolipid-anchored-IL-12 (GPI-IL-12) was constructed by subclonin...

The development of cancer is a major problem in immunosuppressed patients, particularly after solid organ transplantation. We have recently shown that calcineurin inhibitors (CNI) used to treat transplant patients may play a critical role in the rapid progression of renal cancer. To examine the intracellular signaling events for CNI-mediated direct tumorigenic pathway(s), we studied the effect ...

Metastasis of kidney cancer to the bone tissue can be manifested through development pathological fractures and spinal cord lesions. The clinical case clear cell renal carcinoma with solitary metastasis in thoracic spine presented this article demonstrates possibility manifestation disease neurological symptoms importance timely comprehensive diagnosis adherence treatment deadlines.

background: tumor lysis syndrome caused by widespread tumor cell damage may lead to electrolyte imbalances and express as metabolic disturbance causing clinical abnormalities. patients and methods: all patients younger than 16 years with documented malignancy candidate for chemotherapy, in hamedan province of iran were enrolled. results: out of 69 cancer patients the laboratory form of tumor ly...