Background Rheumatoid arthritis (RA) guidelines highlight the importance of early treatment to reduce disease activity and prevent long term damage [1-4]. Infection risk must be considered when starting biologic therapy as infections account for significant morbidity mortality in RA [5]. Tocilizumab sarilumab are anti-interleukin-6 (IL-6) receptor antibodies also effective treating symptoms pre...

The Mcm2-7 complex, the catalytic core of the eukaryotic replicative DNA helicase, undergoes a complex series of transformations at origins of DNA replication. During G1 phase, it is loaded around double-strand DNA at origins as an inactive double hexamer, which is subsequently remodelled in situ to activate the helicase during S phase. Work in this issue of The EMBO Journal sheds light on the ...

A review of editorial policies of leading journals and of research relevant to scientific journals revealed conflicts between 'science' and 'scientists.' Owing to these conflicts, papers are often weak on objectivity and replicability. Furthermore, papers often fall short on importance, competence, intelligibility, or efficiency. Suggestions were made for editorial policies such as: (1) structu...

16 Meiotic cells undergo a single round of DNA replication followed by two rounds of 17 chromosome segregation (the meiotic divisions) to produce haploid gametes. Both DNA 18 replication and chromosome segregation are similarly regulated by CDK oscillations in mitotic 19 cells. Yet how these two events are uncoupled between the meiotic divisions is unclear. Using 20 Saccharomyces cerevisiae, we...

Research in Western Australian schools and reports from studies across the nation over the past decade have supported international research to find that the leadership of a school is a critical factor in the way in which of Information and Communications Technology (ICT) are used, and their subsequent impact on teaching and learning. This paper discusses this relationship by drawing on a range...

Neural networks are good at classification, forecasting and recognition. They are also good candidates of financial forecasting tools. Forecasting is often used in the decision making process. Neural network training is an art. Trading based on neural network outputs, or trading strategy is also an art. We will discuss a seven-step neural network forecasting model building approach in this arti...

•The replication envelope is a new form of motile DNA system•Calcium signaling and cytoskeletal regulation may coordinate the band•Phylogenomics resolves deep phylogeny ciliate phylum ubiquitous conserved cellular process. However, only understood in small fraction organisms that poorly represent diversity genetic systems nature. Here we used computational experimental approaches to examine fun...

International research has consistently found that the organisation and leadership of a school are critical factors in the way in which educational technologies such as computers are used and their subsequent impact on learning opportunities in schools. This involves the Principal but also should involve a leadership team including a Curriculum leader (e.g. Director of Curriculum) who provides ...

Effi e Louise Power (1873–1969) represented the high standard of collaboration among children’s librarians that characterized the entire development of youth services work. This article examines Power’s role in U.S. library history as a practitioner, library and information science educator, national and regional professional leader, and author. Particular emphasis is given to Power’s place in ...