Wnt/β-catenin signalling controls development and adult tissue homeostasis and causes cancer when inappropriately activated. In unstimulated cells, an Axin1-centred multi-protein complex phosphorylates the transcriptional co-activator β-catenin, marking it for degradation. Wnt signalling antagonizes β-catenin proteolysis, leading to its accumulation and target gene expression. How Wnt stimulati...

Wnt/b-catenin signalling controls development and adult tissue homeostasis and causes cancer when inappropriately activated. In unstimulated cells, an Axin1centred multi-protein complex phosphorylates the transcriptional co-activator b-catenin, marking it for degradation. Wnt signalling antagonizes b-catenin proteolysis, leading to its accumulation and target gene expression. How Wnt stimulatio...

Abstract Failure is a normal and critical part of the scientific process; however, admittance failure remains largely stigmatized within sciences. In this paper, we argue that sharing stories should be normalized, not only for advancement knowledge improvement research outcomes, but also health well-being community. We feel particularly important early career researchers, as it will help to set...

Background Global health policy is created largely through a collaborative process between development agencies and aid-recipient governments, yet it remains unclear whether governments retain ownership over the creation of policy in their own countries. An assessment of the power structure in this relationship and its influence over agenda-setting is thus the first step towards understanding w...

This paper presents an experimental study of turbulent non-premixed jet flames ethylene/nitrogen where the nitrogen is substituted with different proportions hydrogen and/or ammonia. The focus largely on effects and ammonia soot production in flames. A combination pointwise, laser-induced fluorescence visible UV bands (LIF-UV–visible), incandescence (LII) used to measure precursors along flame ...