STUDY OBJECTIVES Two commentaries recently published in SLEEP came to very different conclusions regarding how data from a mouse model of sleep-dependent neural plasticity (orientation-specific response potentiation; OSRP) fit with the synaptic homeostasis hypothesis (SHY). To assess whether SHY offers an explanatory mechanism for OSRP, we present new data on how cortical neuron firing rates ar...

Although mesolimbic dopamine (DA) transmission has been implicated in behavioral and cortical arousal, DA neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) are not significantly modulated by anesthetics or the sleep-wake cycle. However, VTA and SN non-DA neurons evince increased firing rates during active wakefulness (AW) and rapid eye movement (REM) sleep, re...

Bemmel, A.L. van and R.H. van den Hoofdakker. Maintenance of therapeutic effects of total sleepdeprivation by means of limitation of subsequent sleep. Abstr. 5th ESRS Congress, Amsterdam,1980.Smeets, E.H.J. and A.L. van Bemmel. Phase-advance of urinary MHPG excretion in normals anddepressives, Abstr. 11th CINP Congress, Florence, 1984.Bemmel, A.L. van, R. van Diest and J.H.M...

Sleep is essential for life. Body systems require sleep of good quantity and quality for their proper functioning. Glucose metabolism can be affected adversely by several sleep disorders. Obstructive sleep apnea (OSA) is one of the most important disorder identified in the last 50 years which has systemic effects including glucose metabolism. Aging process also has its effects on glucose metabo...

Neuronal firing patterns, neuromodulators, and cerebral metabolism change across sleep-waking states, and the synaptic release of glutamate is critically involved in these processes. Extrasynaptic glutamate can also affect neural function and may be neurotoxic, but whether and how extracellular glutamate is regulated across sleep-waking states is unclear. To assess the effect of behavioral stat...

INTRODUCTION PAIN PERCEPTION AND SLEEP ARE FUNDAMENTAL PHYSIOLOGIC PROCESSES REGULATED BY OVERLAPPING BIOLOGIC SUBSTRATES WITHIN THE CENTRAL nervous system (CNS). Conditions associated with dysfunction of these complex systems (eg, chronic pain, insomnia, affective disturbance) are some of the most common, costly, and difficult-totreat problems facing healthcare. Longitudinal studies of chronic...

Sleep is characterized as rapid eye movement (REM) and non-rapid eye movement (NREM) sleep. Studies suggest that wake-related neurons in the basal forebrain, posterior hypothalamus and brainstem, and NREM sleep-related neurons in the anterior-hypothalamic area inhibit each other, thus alternating sleep-wakefulness. Similarly, pontine REM-ON and REM-OFF neurons reciprocally inhibit each other fo...