To the Editor: I read with great interest the article by Leslie et al. describing the electroencephalographic correlates of dreaming during anesthesia. Their conclusion that traits of rapid eye movement (REM) sleep are expressed during emergence from anesthesia is provocative. It is of historical interest to note that a common mechanism of dreaming during both sleep and anesthesia was predicted...

Abstract Introduction Sleep influences various cognitive and physiologic processes; however, the mechanisms through which sleep affects these different functions are not fully understood. The Nucleus Accumbens (NAc) was recently identified as a regulating center. We hypothesized that manipulation of via chemogenetic activation active Adenosine-2A receptor (A2aR) neurons in NAc core could induce...

INTRODUCTION To investigate the course of functional status assessed by health assessment questionnaire (HAQ) in rheumatoid arthritis (RA) patients with sustained clinical remission (REM). METHODS In recent RA clinical trials, we identified patients with subsequent visits of ≥24 weeks in clinical REM according to the disease activity score using 28-joint counts including C-reactive protein (D...

Sleep is composed of an alternating sequence of REM and non-REM episodes, but their respective roles are not known. We found that the overall firing rates of hippocampal CA1 neurons decreased across sleep concurrent with an increase in the recruitment of neuronal spiking to brief "ripple" episodes, resulting in a net increase in neural synchrony. Unexpectedly, within non-REM episodes, overall f...

Respiratory volumes and timing have been measured in 19 healthy adults during wakefulness and sleep. Minute ventilation was significantly less (p less than 0.05) in all stages of sleep than when the subject was awake (7.66 +/- 0.34(SEM) 1/min), the level in rapid-eye-movement (REM) sleep (6.46 +/- 0.29 1/min) being significantly lower than in non-REM sleep (7.18 +/- 0.39 1/min). The breathing p...

Introduction: There are several evidences that show various environmental stresses during pregnancy, affect physiological behavior of the offspring. In this study the effects of REM (Rapid Eye Movement) sleep deprivation of pregnant rats on spatial learning of adult male offspring by Morris water maze were investigated. Methods: Water tank technique was used for inducing REM sleep deprivatio...

During rapid-eye-movement (REM) sleep the ventilatory response to airway occlusion is reduced. Possible mechanisms are reduced chemosensitivity, mechanical impairment of the chest wall secondary to the atonia of REM sleep, or phasic REM events that interrupt or fractionate ongoing diaphragm electromyogram (EMG) activity. To differentiate between these possibilities, we studied three chronically...

Hippocampal electrophysiology and behavioral evidence support a role for sleep in spatial navigational memory, but the role of particular sleep stages is less clear. Although rodent models suggest the importance of rapid eye movement (REM) sleep in spatial navigational memory, a similar role for REM sleep has never been examined in humans. We recruited subjects with severe obstructive sleep apn...

Rapid eye movement (REM) sleep has been shown to be related to many adaptive cognitive and behavioral functions. However, its precise functions are still elusive, particularly in developmental psychiatric disorders. The present study aims at investigating associations between polysomnographic (PSG) REM sleep measurements and neurobehavioral functions in children with common developmental psychi...