Bi-layer tablet is a new era for the successful development of controlled release formulation along with various features to provide a way of successful drug delivery system. Bi-layer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet in which one layer is immediate release as initial dose and second ...

In this study, we examined a possible use of a surface-deacetylated chitin nano-fiber (SDCH-NF) and hyaluronic acid (HA) interpolymer complex (IPC) tablet as a potential antioxidative compound in extended-release matrix tablets. The antioxidant properties of untreated chitin (UCH), SDCH-NF, and HA were examined using N-centered radicals derived from 1,1'-diphenyl-2-picrylhydrazyl (DPPH) and 2,2...

Floating matrix tablets of losartan potassium were developed with an aim to prolong its gastric residence time and increase the bioavailability of drug. Rapid gastrointestinal transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to diminished efficacy of the administered dose. The tablets were prepared by wet granulation technique, usin...

The dissolution characteristics of pharmaceutical tablets are key to determining the bioavailability of the active pharmaceutical ingredient (API) and it is therefore vital to understand the physical processes that affect drug release. As well as the API, tablets also consist of a supporting polymer matrix (known as the excipient) and other compounds such as fillers, binders, lubricants etc. Th...

hypertension crisis is one of the main health problems and its effective treatment is of high importance. for this purpose, fast-disintegrating and sustained release formulations of captopril, as a drug of choice, were prepared using conventional mucoadhesive polymers hydroxypropyl methylcellulose (hpmc), sodium carboxymethyl cellulose (na-cmc), hydroxypropyl cellulose (hpc), carbopol 934 (cp93...

Zolmitriptan is the antimigraine agent widely used for treatment of migraine. It shows half-life 2.5 – 3 h which indicate frequent dosing to achieve proper pharmacological action drug. Gastro Retentive Drug Delivery System (GRDDS) a common approach decrease frequency and increase patient compliance, delivery drug through such an floating tablet formulation will meet requirement. This system sho...

till date, most of the drugs have been given in conventional immediate release dosage form. nimorazole is an anticancer drug, used as a hypoxic radiosensitizer in patients undergoing radiotherapy and no formulation has been available in the market till now. hence, for the purpose to develop an immediate release dosage form, a statistical optimization process has been employed to quantify the ef...

The Development and Assessment of a Herbal Floating Tablet for Peptic Ulcer Disease. goal creating herbal floating tablet is to extend the drugs duration in gastrointestinal tract. This will increase bioavailability result greater absorption than with convectional dose form. Due its gastro-retentive feature, medicine remains at site inflammation longer amount time, resulting more targeted actio...

This study was performed to design bilayer floating tablets of simvastatin and lovastatin to give sustained release of simvastatin and immediate release of lovastatin. Bilayer floating tablets comprised of two layers i.e, immediate and sustained release layers. Bilayer floating tablets of simvastatin and lovastatin was formulated by using HPMCK 100M and super disintegrants like sodium alginate,...