In order to identify direct and transient changes in human cortex under influence of the training with audio-visual stimulation (AVS) various EEG measures were estimated. In the course of 2 months, 25 repetitions of a 20 min AVS program with stimulation frequencies in the range 2-18 Hz were applied to 6 healthy volunteers. EEG data were recorded from 6 head locations during relaxed wakefulness ...

We have used NMR spectroscopy to measure haem disorder in adult human haemoglobin (HbA) obtained from mature erythrocyte cells and from yeast expressing recombinant HbA. Reticulocyte-derived HbA contained much higher levels of haem disorder (11% alpha- and 28% beta-subunit disorder) than observed for HbA from mature erythrocytes (1.5% alpha- and 8% beta-subunit disorder). Thus, unlike in vitro ...

In proteins, the proline ring exists predominantly in two discrete states. However, there is also a small but significant amount of flexibility in the proline ring of high-resolution protein structures. We have found that this side-chain flexibility is coupled to the backbone conformation. To study this coupling, we have developed a model that is simply based on geometric and steric factors and...

We consider an optimal control problem described by semilinear parabolic partial differential equations, with control and state constraints. Since this problem may have no classical solutions, it is also formulated in the relaxed form. The classical control problem is then discretized by using a finite element method in space and the implicit Crank-Nicolson midpoint scheme in time, while the co...