The computer program ASAPprime® has been used successfully for some time to predict the stability of active pharmaceutical ingredients (APIs) in solid-dosage forms. In this study, we have demonstrated that the ASAPprime® program can also be used to predict the slow-down in dissolution of two APIs in an immediate release tablet. The tablets were pre-equilibrated at 25 °C at different relative hu...

Maritime pine (Pinus pinaster) wood has low dimensional stability and durability. Heat treatment was made in an oven using hot air during 2 to 24 h and at 170-200 oC. A comparison was made against steam heat treatment. The equilibrium moisture content and the dimensional stability (ASE) in radial and tangential directions were evaluated at 35%, 65%, and 85% relative humidity. MOE, bending stren...

Aerosols of Mycoplasma pneumoniae were prepared at each of eight relative humidities between 0 and 85% and at five separate temperatures between 10 and 43 C. Survival of these organisms was found to be a function of both relative humidity and temperature. However, the temperature response was mediated by humidity in that the effects of temperature could be observed only if some water vapor was ...