The presence of active transforming growth factor-beta (TGF-beta) in serum has not been widely accepted. In particular, although at least five studies have concluded that active TGF-beta is present in normal human plasma and serum, assays that use the extracellular domain of the TGF-beta type II receptor as a capture agent have given contradictory results. We show that there is an antagonist pr...

Peptide growth factors have been implicated in progression of prostate cancer (PCa) to the androgen-independent state; however, much of the evidence linking diffusible mitogens and survival factors to this process remains circumstantial. Heparin-binding epidermal growth factor-like growth factor (HB-EGF), a prostate stroma-derived factor, promotes survival, proliferation, and neuroendocrine dif...

This work focuses the circumstantial knowledge management for a specific need: the achievement of Natural Interaction (NI). In first place, a cognitive approach to NI is glanced as the framework for such knowledge management. This approach reflects some certain requirements for the whole interaction system, which are met by a multi-agent system implementation. Finally, a Situation Modeling is p...

We begin with a brief discussion of the building blocks of supersymmetric grand unified theories. We recall some of the compelling theoretical reasons for viewing supersymmetric grand unification as an attractive avenue for physics beyond the standard model. This is followed by a discussion of some of the circumstantial evidence for these ideas. Invited Speaker at the XII DAE Symposium on High ...

The control of health care costs continues to be the primary goal of managed care. Double digit inflation in the health care sector continues to be problematic; although society as a whole has not declared what fraction of economic productivity is properly applied to health care. No student of the subject can help but be impressed by the circumstantial evidence that suggests that society is beg...

While it would seem obvious that dose intensity is an important determinant of treatment outcome in aggressive lymphomas, actually there are very few prospective data to support this hypothesis. Circumstantial evidence derived from retrospective analyses suggests that dose intensity is of clinical significance. However, based on available phase II and III data and the one prospective randomized...

features. In the last 5 years or so, very deep networks have indeed been found to achieve startlingly good performance on a wide variety of problems in vision and other application areas; for this reason, the research area of neural networks is often referred to as deep learning. There is some circumstantial evidence that deep networks learn hierarchical representations, but this is notoriously...

We propose a lightweight, practical approach to check mass maintenance transformations. We present checks for both transformation tools and transformed source code, and illustrate them using examples of real-world transformations. Our approach is not a fully fledged, formal one but provides circumstantial evidence for transformation correctness, and has been applied to the mass maintenance of i...

This paper examines the origins of language, as treated within Evolutionary Anthropology, under the light offered by a biolinguistic approach. This perspective is presented first. Next we discuss how genetic, anatomical, and archaeological data, which are traditionally taken as evidence for the presence of language, are circumstantial as such from this perspective. We conclude by discussing way...