Regular packed cell transfusion in patients with thalassemia major leads to iron overload. Chelation therapy is one of the important aspects of thalassemia care as iron overload causes significant cardiac, hepatic, and endocrine dysfunction. We report a case of thalassemia major with severe iron overload causing cardiac and liver dysfunction who benefitted from triple drug chelation therapy. Tr...

Retinal bipolar, amacrine and ganglion cells contact each other within precisely defined synaptic laminae, but the spatial distribution of contacts between the cells is generally treated as random. Here, we show that not to be the case. Excitatory inputs to inner retinal neurons were visualized by introduction of a plasmid coding for the postsynaptic protein PSD95-GFP. Our initial finding was t...

Hexagonal packing geometry is a hallmark of close-packed epithelial cells in metazoans. Here, we used fiber cells of the vertebrate eye lens as a model system to determine how the membrane skeleton controls hexagonal packing of post-mitotic cells. The membrane skeleton consists of spectrin tetramers linked to actin filaments (F-actin), which are capped by tropomodulin1 (Tmod1) and stabilized by...

It is known from many theoretical studies that ecological chaos may have numerous significant impacts on the population and community dynamics. Therefore, identification of the factors potentially enhancing or suppressing chaos is a challenging problem. In this paper, we show that chaos can be enhanced by the Allee effect. More specifically, we show by means of computer simulations that in a ti...

objective(s):multidrug resistance (mdr) of cancer cells is a major obstacle to successful chemotherapy. overexpression of breast cancer resistance protein (bcrp) is one of the major causes of mdr. in addition, it has been shown that pi3k/akt signaling pathway involves in drug resistance. therefore, we evaluated the effects of novel approaches including sirna directed against bcrp and targeted t...

Dynamo models for the structure of the regular magnetic field in the galaxy NGC 6946 are confronted with recent observations of polarized radio emission at λ3.5 cm. The observed behaviour of the concentration of regular fields between the gaseous spiral arms (“magnetic spiral arms”) is achieved via a non-axisymmetric azimuthal distribution of only the correlation time τcorr of interstellar turb...

The classic result of Bulow and Klemperer [1] says that in a singleitem auction recruiting one more bidder and running the Vickrey auction achieves a higher revenue than the optimal auction’s revenue on the original set of bidders, when values are drawn i.i.d. from a regular distribution. We give a version of Bulow and Klemperer’s result in settings where bidders’ values are drawn from non-i.i....

One of the major issues examined in the quantitative ecology is the spatial distribution pattern of plant species. Knowledge of the spatial distribution patterns is essential to measure the level of uniformity in the surrounding environment, plant reproduction, and distribution of the seedlings, plant behavioral patterns, coexistence, allelopathic relations, and competition. Therefore, the aim ...