Recent years have seen an increasing interest in developing robust, accurate and possibly fast forecasting methods for both energy production consumption. Traditional approaches based on linear architectures are not able to fully model the relationships between variables, particularly when dealing with many features. We propose a Gradient-Boosting–Machine-based framework forecast demand of mixe...

The value of an American option is the maximized discounted cash flows from option. At each time step, one needs to compare immediate exercise with continuation and decide as soon strictly greater than value. We can formulate this problem a dynamic programming equation, where main difficulty comes computation conditional expectations representing values at step. In (Longstaff Schwartz, 2001), t...

The group A streptococcal M protein is an important virulence determinant eliciting protective and autoimmune responses against the streptococcus and cardiac myosin, respectively. In this report, the major human cardiac myosin-cross-reactive T-cell epitopes of M5 protein are identified and localized to myosin-like repeats within the M5 molecule. BALB/c mice were immunized with human cardiac myo...

To assess the possible existence of unbalanced chromosomal abnormalities and delineate the characterization of copy number alterations (CNAs) of acute myeloid leukemia-M5 (AML-M5), R-banding karyotype, oligonucelotide array CGH and FISH were performed in 24 patients with AML-M5. A total of 117 CNAs with size ranging from 0.004 to 146.263 Mb was recognized in 12 of 24 cases, involving all chromo...

We present a novel methodology for regression trees generation that uses the reinforcement learning frame for learning efficient regression trees. We describe the basic variant of such a methodology that uses the Monte-Carlo method to explore the space of possible regression trees. Comparison with other methods of regression is performed and evaluated. Our algorithm is implemented as a software...

Mature dolichol-linked oligosaccharides (mDLOs) needed for eukaryotic protein N-glycosylation are synthesized by a multistep pathway in which the biosynthetic lipid intermediate Man5GlcNAc2-PP-dolichol (M5-DLO) flips from the cytoplasmic to the luminal face of the endoplasmic reticulum. The endoplasmic reticulum membrane protein Rft1 is intimately involved in mDLO biosynthesis. Yeast genetic an...

We address the task of modeling dynamical systems in discrete time using regression trees, model trees and option trees for on-line regression. Some challenges that modeling dynamical systems pose to data mining approaches are described: these motivate the use of methods for mining data streams. The algorithm FIMT-DD for mining data streams with regression or model trees is described, as well a...