PURPOSE To assess the effectiveness of a keratoconus-detection algorithm derived from Artemis very high-frequency (VHF) digital ultrasound (ArcScan Inc., Morrison, CO) epithelial thickness maps in the fellow eye from a series of patients with unilateral keratoconus. METHODS The study included 10 patients with moderate to advanced keratoconus in one eye but a clinically and algorithmically top...

Purpose: To compare the corneal parameters in normal corneas, forme fruste keratoconus (FFKC) and keratoconus measured with a dual Scheimpflug analyzer. Materials and methods: A total of 372 eyes of 197 patients were prospectively enrolled in the study and divided into three groups: 148 eyes of 102 patients with keratoconus, 47 contralateral topographically normal eyes of clinically evident ker...

Introduction: Keratoconus is a relatively common disease of cornea in which structural changes within the cornea cause it to thin and change to a conical shape and scar at the central portion of cornea. So far, few methods and drug treatments were introduced due to both lack of accepted animal models to induce experimental keratoconus and limitation of research in human considering ethical issu...

In this review, we analyzed the domestic and foreign literature on use of corneal lenticula obtained by keratorefractive surgery using SMILE technology (SMall Incision Lenticula Extraction). Research is being actively carried out a lenticular tissue for refractive purposes: correction hyperopia (LIKE – Lenticular Intrastromal Keratoplasty), presbyopia (PEARL PrEsbyopic Allogenic Refractive Lent...

PURPOSE Mutations in the visual system homeobox 1 (VSX1) gene have been described at a low frequency in keratoconus and posterior polymorphous corneal dystrophy (PPCD). The putative role is controversial for several reasons, including a lack of mutations detected in other population cohorts. This study aims to determine whether VSX1 contributes to the genetic pathogenesis of keratoconus and PPC...

KERATOCONUS is comparatively speaking a rare disease, but as a clinical entity it has been known for many years. Its aetiology is, however, still obscure, and its treatment is unfortunately one of the failures of ophthalmology. It has been thought that it might be a deficiency disease, and recent attempts to cure the condition by administration of vitamin D and calcium have been made. (Knapp, 1...

Background and aims: Keratoconus is characterized by corneal ectasia and irregular astigmatism, which can lead to diminished vision and corneal scarring. Keratoconus is a condition that causes corneal ectasia and reduced vision in young adults. A proportion of these patients have progressive disease requiring corneal transplantation. Methods: The databases searched included OVID MEDLINE, MEDLIN...

PURPOSE A mutation miR-184(+57C>T) in the seed region of miR-184 (encoded by MIR184 [MIM*613146]) results in familial severe keratoconus combined with early-onset anterior polar cataract and endothelial dystrophy, iris hypoplasia, congenital cataract, and stromal thinning (EDICT) syndrome (MIM#614303). In order to investigate the phenotypic spectrum resulting from MIR184 mutation, MIR184 was se...

Keratoconus is a degenerative disorder with progressive stromal thinning and transformation of the normal corneal architecture towards ectasia that results in decreased vision due to irregular astigmatism and irreversible tissue scarring. The pathogenesis of keratoconus still remains unclear. Hypotheses that this condition has an inflammatory etiopathogenetic component apart from the genetic an...

Corneal hysteresis (CH) is a parameter which measures the viscoelastic behaviour of the cornea, indicating its biomechanical integrity1. Some clinical conditions such as keratoconus, Fuchs corneal dystrophy, high myopia, glaucoma and corneal refractive surgery, may induce changes in corneal biomechanical properties, leading to a decrease in CH2-6. Astigmatism, a refractive error related to corn...